24678-65-7Relevant articles and documents
Van.ebeek et al.
, p. 2204,2205, 2208 (1970)
Synthesis and characterization of the first Te(IV) organometallic complexes with azepane-1-carbodithioate
Cotero-Villegas, Ave María,Moya-Cabrera, Mónica,Jancik, Vojtech,Pérez-Redondo, María del Carmen,Martínez-Salas, Patricia,Cea-Olivares, Raymundo
, p. 338 - 343 (2017)
We report the synthesis and spectroscopic characterization of organometallic Te(IV) complexes bearing the seven-membered azepane-1-carbodithioate ligand and four different types of tellurium(IV) heterocycles; [C4H8Te{S2C-N(CH2)6}2](2),[C8H8Te{S2C-N(CH2)6}2](3),[C4H8OTe{S2C-N(CH2)6}2](4)and [C5H10Te{S2C-N(CH2)6}2](5). Compounds 2–5, obtained in a 2:1 stoichiometric ratio, are air-stable for long periods of time, but readily decompose in solution. They have been characterized by elemental analyses, IR, FAB+–MS, and multinuclear NMR (1H,13C, and125Te) spectroscopy. The molecular structures of 2 and 5 were established by single-crystal X-ray diffraction studies. The geometrical arrangement around the tellurium atom can be described as a distorted trigonalbipyramid or sawhorse structure, typical for tellurium atom, where the lone pair is apparently stereochemically active, occupying an equatorial position. The coordination mode for the azepane-1-carbodithioate ligands is considered as anisobidentate. Due to the orthogonal arrangement of the dithiocarbamate groups around tellurium, it is difficult for other atoms to approach and in consequence there are not intermolecular secondary interactions.
Substituted carbamothioic amine-1-carbothioic thioanhydrides as novel trichomonicidal fungicides: Design, synthesis, and biology
Mandalapu, Dhanaraju,Kushwaha, Bhavana,Gupta, Sonal,Krishna, Shagun,Srivastava, Nidhi,Shukla, Mahendra,Singh, Pratiksha,Chauhan, Bhavana S.,Goyani, Ravi,Maikhuri, Jagdamba P.,Sashidhara, Koneni V.,Kumar, Brijesh,Tripathi, Renu,Shukla, Praveen K.,Siddiqi, Mohammad I.,Lal, Jawahar,Gupta, Gopal,Sharma, Vishnu L.
, p. 632 - 645 (2017/12/08)
Sexually transmitted diseases like trichomoniasis along with opportunistic fungal infections like candidiasis are major global health burden in female reproductive health. In this context a novel non-nitroimidazole class of substituted carbamothioic amine-1-carbothioic thioanhydride series was designed, synthesized, evaluated for trichomonacidal and fungicidal activities, and was found to be more active than the standard drug Metronidazole (MTZ). Compounds were trichomonicidal in the MIC ranges of 4.77–294.1 μM and 32.46–735.20 μM against MTZ-susceptible and -resistant strains, respectively. Further, compounds inhibited the growth of at least two out of ten fungal strains tested at MIC of 7.50–240.38 μM. The most active compound (20) of this series was 3.8 and 9.5 fold more active than the MTZ against the two Trichomonas strains tested. Compound 20 also significantly inhibited the sulfhydryl groups present over Trichomonas vaginalis and was found to be more active than the MTZ in vivo. Further, a docking analysis carried out with cysteine proteases supported their thiol inhibiting ability and preliminary pharmacokinetic study has shown good distribution and systemic clearance.
