279220-39-2Relevant articles and documents
Synthesis and evaluation of 'AZT-HEPT', 'AZT-pyridinone', and 'ddC-HEPT' conjugates as inhibitors of HIV reverse transcriptase
Pontikis, Renée,Dollé, Valérie,Guillaumel, Jean,Dechaux, Elsa,Note, Reine,Nguyen, Chi Hung,Legraverend, Michel,Bisagni, Emile,Aubertin, Anne-Marie,Grierson, David S.,Monneret, Claude
, p. 1927 - 1939 (2007/10/03)
To test the concept that HIV reverse transcriptase could be effectively inhibited by 'mixed site inhibitors', a series of seven conjugates containing both a nucleoside analogue component (AZT 1, ddC 2) and a nonnucleoside type inhibitor (HEPT analogue 12,