333-18-6 Usage
Description
Ethylenediamine dihydrochloride is an organic compound with the chemical formula C2H8N2·2HCl. It is a white crystalline solid that is soluble in water and has a variety of applications across different industries due to its unique chemical properties.
Uses
Used in Pharmaceutical Industry:
Ethylenediamine dihydrochloride is used as a stabilizer in steroid creams and as an active ingredient in nystatin cream and aminophylline for treating various medical conditions.
Used in Chemical Industry:
Ethylenediamine dihydrochloride is used as an inhibitor in antifreeze solutions and cooling fluids, as an epoxy-curing agent, and as an accelerator in color development baths in photography.
Used in Household and Personal Care Products:
Ethylenediamine dihydrochloride is used in floor-polish remover, eye and nose drops, and as a solvent for casein, albumin, and shellac.
Used in Veterinary Preparations:
Ethylenediamine dihydrochloride is used in the formulation of veterinary preparations for treating various animal health issues.
Used in Agriculture:
Ethylenediamine dihydrochloride is used in the production of dyes, fungicides, insecticides, synthetic waxes, and textile lubricants.
Used in Electroplating and Electrophoretic Gels:
Ethylenediamine dihydrochloride is used as a component in electroplating and electrophoretic gels for various applications.
Used in Analytical Chemistry:
Ethylenediamine dihydrochloride was used in the modified ethylenediamine condensation method for the fluorimetric determination of catecholamines and in the investigation of the luminescence properties of complexes of EuIII and TbIII with ethylenediamine.
Used in Organic Synthesis:
Ethylenediamine dihydrochloride is used in the synthesis of 1,3,5-tris(4,5-dihydro-1H-imidazol-2-yl)benzene, a compound with potential applications in various fields.
Safety Profile
Moderately toxic by
ingestion. Experimental teratogenic and
reproductive effects. When heated to
decomposition it emits very toxic fumes of
HCl and NOx.
Purification Methods
Crystallise the salt from H2O or H2O/EtOH. Wash the crystals with EtOH and dry them in vacuo. It sublimes on heating. [Beilstein 4 IV 1168.]
Check Digit Verification of cas no
The CAS Registry Mumber 333-18-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,3 and 3 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 333-18:
(5*3)+(4*3)+(3*3)+(2*1)+(1*8)=46
46 % 10 = 6
So 333-18-6 is a valid CAS Registry Number.
InChI:InChI=1/C4H6N2O2/c1-2-8-4(7)3-6-5/h3H,2H2,1H3
333-18-6Relevant articles and documents
Morgan, G. T.,Burstall, F. H.
, (1926)
Identifying the roles of amino acids, alcohols and 1,2-diamines as mediators in coupling of haloarenes to arenes
Zhou, Shengze,Doni, Eswararao,Anderson, Greg M.,Kane, Ryan G.,Macdougall, Scott W.,Ironmonger, Victoria M.,Tuttle, Tell,Murphy, John A.
supporting information, p. 17818 - 17826 (2015/02/19)
Coupling of haloarenes to arenes has been facilitated by a diverse range of organic additives in the presence of KOtBu or NaOtBu since the first report in 2008. Very recently, we showed that the reactivity of some of these additives (e.g., compounds 6 and 7) could be explained by the formation of organic electron donors in situ, but the role of other additives was not addressed. The simplest of these, alcohols, including 1,2-diols, 1,2-diamines, and amino acids are the most intriguing, and we now report experiments that support their roles as precursors of organic electron donors, underlining the importance of this mode of initiation in these coupling reactions.
Hydrolysis of cyclic ureas under microwave irradiation: Synthesis and characterization of 7,8-diaminopelargonic acid
Vasanthakumar, Ganga Ramu,Bhor, Vikrant M.,Surolia, Avadhesha
, p. 2633 - 2639 (2008/02/12)
A simple and efficient method for the synthesis of 7,8-diaminopelargonic acid, a key intermediate in the biotin biosynthesis pathway, is reported. The d-desthiobiotin powder was dissolved in concentrated hydrochloric acid, and the solution was exposed to microwave radiation of 2.45 GHz for varying lengths of time ranging from 60 s to 2 min. The product thus obtained was characterized by spectroscopic techniques and confirmed through bioassay. Further, the protocol was extended to the synthesis of several diamines from their corresponding cyclic ureas. The results show that the method is generally applicable and not only accelerates the hydrolysis reaction but also offers excellent yields. Copyright Taylor & Francis Group, LLC.
