34916-10-4

Basic information

• Product Name: CYCLOHEXANECARBONITRILE, 4-OXO-
• Synonyms: 4-OXOCYCLOHEXANECARBONITRILE;CYCLOHEXANECARBONITRILE, 4-OXO-;4-Isocyanocyclohexanone, 99%;4-cyano-cyclohexanone;4-oxocyclohexane-1-carbonitrile;4-OXOCYCLOHEXANECARBONITRILE(WXC05700)
• CAS NO: 34916-10-4
• Molecular Formula: C₇H₉NO
• Molecular Weight: 123.154
• Mol File: 34916-10-4.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 271℃
• Flash Point: 118℃
• Appearance: /
• Density: 1.05
• Vapor Pressure: 0.007mmHg at 25°C
• Refractive Index: 1.465
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• CAS DataBase Reference: CYCLOHEXANECARBONITRILE, 4-OXO-(CAS DataBase Reference)
• NIST Chemistry Reference: CYCLOHEXANECARBONITRILE, 4-OXO-(34916-10-4)
• EPA Substance Registry System: CYCLOHEXANECARBONITRILE, 4-OXO-(34916-10-4)

Safety Data

• Hazardous Substances Data: 34916-10-4(Hazardous Substances Data)

Usage

Description

Cyclohexanecarbonitrile, 4-oxo-, also known as 4-Cyanocyclohexanone, is an organic compound with the molecular formula C7H9NO. It is a key intermediate in the synthesis of various pharmaceuticals and chemicals due to its unique structure and reactivity.

Uses

Used in Pharmaceutical Industry:
Cyclohexanecarbonitrile, 4-oxois used as a key intermediate for the preparation of nicotinamides, which serve as phosphodiesterase 4 (PDE4) D isoenzyme inhibitors. These inhibitors play a crucial role in treating various inflammatory and autoimmune diseases by modulating the immune response and reducing inflammation.
Additionally, Cyclohexanecarbonitrile, 4-oxois used as an anthranilic acid replacement in the synthesis of niacin receptor agonists. These agonists are important for the treatment of various conditions, including hypercholesterolemia, atherosclerosis, and other cardiovascular diseases, as they help regulate lipid metabolism and improve overall cardiovascular health.

InChI:InChI=1/C7H9NO/c8-5-6-1-3-7(9)4-2-6/h6H,1-4H2

Upstream product

• 143-33-9 sodium cyanide 
• 108-94-1 cyclohexanone 
• 19158-51-1 P-toluenesulfonyl cyanide 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 100-45-8 3-cyclohexene-1-carbonitrile 
• 112497-89-9 4-[(trimethylsilyl)oxy]cyclohex-3-ene-1-carbonitrile 
• 69947-09-7 1,4-dioxaspiro<4.5>decane-8-carbonitrile 
• 58774-05-3 1-cyano-4-pyrrolidin-1-yl-cyclohex-3-enecarboxylic acid ethyl ester 

Downstream Products

• 874-61-3 4-oxocyclohexanecarboxylic acid 
• 24056-34-6 4-hydroxycyclohexane-1-carbonitrile 
• 108236-58-4 4-(2,4-dinitro-phenylhydrazono)-cyclohexanecarboxylic acid 
• 97087-59-7 α-(3-aminocyclohexyl)methylamine 
• 13338-82-4 1-amino-4-(aminomethyl)cyclohexane 
• 10282-31-2 4-morpholinobenzonitrile 
• 96795-43-6 4-(di-n-propylamino)benzonitrile 
• 186650-98-6 tert-butyl 4-(4-cyanophenyl)piperazine-1-carboxylate 
• 34334-28-6 4-(4-methylpiperazin-1-yl)benzonitrile 
• 927699-35-2 4-(2,6-dimethylmorpholino)benzonitrile 
• 344566-78-5 tert-butyl (1-(4-cyanophenyl)piperidin-4-yl)carbamate 
• 352018-90-7 1-(4-cyanophenyl)-piperidine-4-carboxylic acid ethyl ester 
• 85872-87-3 4-(4-methylpiperidin-1-yl)-benzonitrile 
• 10282-30-1 4-pyrrolidin-1-yl-benzonitrile 

Relevant articles and documents

Direct C(sp3)-H Cyanation Enabled by a Highly Active Decatungstate Photocatalyst

A highly efficient, direct C(sp3)-H cyanation was developed under mild photocatalytic conditions. The method enabled the direct cyanation of various C(sp3)-H substrates with excellent functional group tolerance. Notably, complex natural products and bioactive compounds were efficiently cyanated.

Preparation method for 4-cyanocyclohexanone

The invention provides a preparation method for 4-cyanocyclohexanone. The preparation method mainly overcomes the technical problems that conventional synthesis methods have high cost, great consumption of organic solvents and environmental pollution and

Corresponding amine nitrile and method of manufacturing thereof

The invention relates to a manufacturing method of nitrile. Compared with the prior art, the manufacturing method has the characteristics of significantly reduced using amount of an ammonia source, low environmental pressure, low energy consumption, low production cost, high purity and yield of a nitrile product and the like, and nitrile with a more complex structure can be obtained. The invention also relates to a method for manufacturing corresponding amine from nitrile.