42512-59-4

Basic information

• Product Name: 1-(4-Hydroxy-4-phenyl-but-2-ynyl)-cyclopentanol
• Synonyms: 1-(4-Hydroxy-4-phenyl-but-2-ynyl)-cyclopentanol
• CAS NO: 42512-59-4
• Molecular Weight: 230.307
• Mol File: 42512-59-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(4-Hydroxy-4-phenyl-but-2-ynyl)-cyclopentanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Hydroxy-4-phenyl-but-2-ynyl)-cyclopentanol(42512-59-4)
• EPA Substance Registry System: 1-(4-Hydroxy-4-phenyl-but-2-ynyl)-cyclopentanol(42512-59-4)

Safety Data

• Hazardous Substances Data: 42512-59-4(Hazardous Substances Data)

Upstream product

• 19135-07-0 1-(prop-2-ynyl)cyclopentanol 
• 100-52-7 benzaldehyde 

Downstream Products

• 1239487-48-9 8,9-diiodo-7-phenyl-6-oxaspiro[4.5]dec-8-ene 
• 40485-29-8 4-(1-hydroxy-cyclopentyl)-1-phenyl-but-2-yn-1-one 

Relevant articles and documents

Synthesis of five- and six-membered dihalogenated heterocyclic compounds by electrophile-triggered cyclization

Highly substituted dihalogenated dihydrofurans, dihydropyrroles, and dihydro-2H-pyrans bearing alkyl, vinyl, aryl, and heteroaryl moieties can be prepared in good to excellent yields (up to 99%) by allowing 1,4-butyne-diol, 4-aminobut-2-yn-1-ol, and pent-2-yne-1,5-diol derivatives to react with different electrophiles (I2, IBr, and ICl) at room temperature. Both halogen atoms generated from electrophiles were used effectively. The resulting halides can be further exploited by using palladium-catalyzed coupling reactions. The presence of trace amount of water is essential for this electrophilic cyclization.