510758-28-8

Basic information

• Product Name: TBTA
• Synonyms: Tris[(1-benzyl-1H-1,2,3-triazol-4-yl)Methyl]aMine 97%;1-(1-Benzyltriazol-4-yl)-N,N-bis[(1-benzyltriazol-4-yl)methyl]methanamine;N,N,N-Tris[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl]amine;Tris-(benzyltriazolylmethyl)amine;Tris[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl]amine;Tris[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl]amine, 97% TBTA
• CAS NO: 510758-28-8
• Molecular Formula: C30H30N10
• Molecular Weight: 530.6262
• EINECS: -0
• Mol File: 510758-28-8.mol
• Article Data: 0

Chemical Properties

• Melting Point: 132-143℃
• Boiling Point: 762.4±70.0 °C(Predicted)
• Appearance: White/Solid
• Density: 1.27±0.1 g/cm3(Predicted)
• Storage Temp.: ?20°C
• Solubility: Soluble in DMSO, DMF.
• PKA: 2.44±0.50(Predicted)
• Stability: store cold
• CAS DataBase Reference: TBTA(CAS DataBase Reference)
• NIST Chemistry Reference: TBTA(510758-28-8)
• EPA Substance Registry System: TBTA(510758-28-8)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 510758-28-8(Hazardous Substances Data)

Usage

Description

TBTA, or Tris-(benzyltriazolylmethyl)amine, is a water-insoluble ligand introduced to address the thermodynamic instability of Cu(I) in aerobic media, particularly following the discovery of the copper-catalyzed azide-alkyne cycloaddition reaction. TBTA must be initially dissolved in DMSO or DMF before use.
Used in Chemical Synthesis:
TBTA is used as a reagent in copper (I) catalyzed azide-alkyne cycloadditions, a reaction that is crucial for the formation of triazole-linked products. Its role in stabilizing the copper catalyst is vital for the success of these reactions.
Used in Biochemistry:
TBTA is used for postsynthetic labeling of alkyne-modified DNA. This application takes advantage of the reagent's ability to facilitate copper-catalyzed reactions, allowing for the attachment of various functional groups to DNA molecules for further study or manipulation.

Downstream Products

• 1402266-93-6 C₃₀H₂₉N₅O₆