542-52-9Relevant articles and documents
New Synthetic Approach to Polyfluorinated Carbonates
Ezhikova, M. A.,Kodess, M. I.,Pestov, A. V.,Semenova, A. M.,Zapevalov, A. Ya.
, (2020)
Abstract: Transesterification of commercial titanium(IV) alkoxides with2,2,3,3-tetrafluoropropan-1-ol, followed by in situ transesterification of mixedtitanium(IV) alkoxides thus formed with diphenyl carbonate, afforded alkyl2,2,3,3-tetrafluoropropyl carb
Microwave-Assisted Aminoalkylation of Phenols via Mustard Carbonate Analogues
Annatelli, Mattia,Aricò, Fabio,Castellano, Sabrina,Milite, Ciro,Trapasso, Giacomo,Viviano, Monica
supporting information, (2022/03/17)
microwave-assisted chlorine-free direct phenol substitution is presented, which is indicated as a key green chemistry research area for pharmaceuticals manufacturers. The reaction of -aminocarbonates (mustard carbonates) with several substituted phenols in the presence of a polar solvent (acetonitrile or butanol) led to the related aminoalkylated products via the anchimeric assistance of the nitrogen incorporated in the organic carbonate backbone. The aminoalkylation required short reaction time (7 min) and the related products were isolated in high yields (>90%) via quick liquid-liquid extraction or column chromatography depending on the solvent employed. Furthermore, microwave irradiation also promoted the one-pot aminoalkylation of phenol in excellent yield. In this approach a -aminoalcohol was reacted with phenol in the presence of diethyl carbonate, used for the in situ formation -aminocarbonate, key intermediate in the consequent anchimerically driven alkylation. The resulting product, namely N,N-dimethyl- 2-phenoxyethanamine, was isolated as pure in almost quantitative yield.
Phosgene-free synthesis of symmetric bis(polyfluoroalkyl) carbonates
Semenova, Anna M.,Ezhikova, Marina A.,Kodess, Mikhail I.,Zapevalov, Aleksandr Ya.,Pestov, Aleksandr V.
, p. 257 - 258 (2021/05/04)
A phosgene-free synthesis of symmetric bis(polyfluoroalkyl) carbonates involves the transesterification of diphenyl carbonate with polyfluoroalkanols promoted by stoichiometric amounts of titanium(iv) alkoxides.
Synthesis of dimethyl carbonate from methanol and CO2under low pressure
Liu, Chun,Liu, Kai
, p. 35711 - 35717 (2021/12/04)
A mild and highly efficient approach has been developed for the direct synthesis of dimethyl carbonate (DMC) from methanol and CO2 under low initial pressure. The key to a successful transformation is the use of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), CH2Br2 and ionic liquid. Under the optimized reaction conditions, the yield of DMC was obtained up to 81% under 0.25 MPa. The direct synthesis of DMC can be carried out at balloon pressure using CH2Br2 and DBU. In this case, after the reaction, DBU was proved to be recyclable after having been treated with KOH in ethanol. In addition, a plausible mechanism for this synthetic reaction was proposed according to the experimental results.