606-17-7 Usage
Description
IODIPAMIDE is a water-soluble, nonionic, iodinated contrast agent used in medical imaging for various diagnostic procedures. It is formulated as an aqueous solution containing iodine, which provides the radiopaque properties necessary for visualizing internal structures during imaging. IODIPAMIDE is known for its low osmolarity, which reduces the risk of adverse effects and makes it suitable for use in patients with compromised renal function.
Uses
Used in Medical Imaging:
IODIPAMIDE is used as a radiopaque medium in cholecystographic procedures for the visualization of the gallbladder and bile ducts. Its water-soluble and nonionic properties allow for better tolerability and reduced risk of adverse reactions compared to ionic contrast agents.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, IODIPAMIDE is utilized as an antihypertensive and diuretic agent. It works by activating potassium channels and AMPA receptors, which helps in lowering blood pressure and promoting the excretion of excess fluid from the body. This makes it a valuable component in the treatment of hypertension and fluid retention-related conditions.
Originator
Cholografin,Squibb,US,1954
Manufacturing Process
125 g of 2,4,6-triiodo-3-amino benzoic acid are dissolved in 250 cc of
chlorobenzene and 15 g of adipic acid dichloride are added at a temperature
between 110° and 130°C drop by drop to the solution. After evolution of
hydrochloric acid (about 2 to 3 hours) has ceased, the precipitated crude
adipic acid di-(3-carboxy-2,4,6-triiodo anilide) of the above formula is filtered
hot with suction, washed with chlorobenzene, extracted by boiling with
methanol and, for purification, dissolved in an amount of methanolic caustic
soda solution required for neutralization, filtered with charcoal, and
precipitated with dilute hydrochloric acid. Yield: 82.3 g, MP 306° to 308°C
(with decomposition).
Therapeutic Function
Diagnostic aid (radiopaque medium)
Hazard
Toxic by ingestion.
Check Digit Verification of cas no
The CAS Registry Mumber 606-17-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,0 and 6 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 606-17:
(5*6)+(4*0)+(3*6)+(2*1)+(1*7)=57
57 % 10 = 7
So 606-17-7 is a valid CAS Registry Number.
InChI:InChI=1/C20H14I6N2O6/c21-7-5-9(23)17(15(25)13(7)19(31)32)27-11(29)3-1-2-4-12(30)28-18-10(24)6-8(22)14(16(18)26)20(33)34/h5-6H,1-4H2,(H,27,29)(H,28,30)(H,31,32)(H,33,34)
606-17-7Relevant articles and documents
Liebster et al.
, p. 1474 (1959)
Iodinated aromatic propanedioates
-
, (2008/06/13)
Compounds having the structure STR1 where (Z--COO is the residue of an iodinated aromatic acid; R1 and R2 are independently alkyl, fluoroalkyl, cycloalkyl, aryl or aralkyl; and R3 is H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, cyano, sulfonate, carboxamido, sulfonamido, CO2 -alkyl, CO2 -aryl or CO2 -aralkyl; are useful as contrast agents in x-ray imaging compositions and methods.
