616-27-3 Usage
Description
1-Chlorobutanone, also known as 3-chloro-2-butanone or chloroacetone, is an organic compound that belongs to the family of ketones. It is a colorless to pale yellow liquid with a pungent odor and is commonly used as a chemical intermediate or reagent in organic synthesis. 1-Chlorobutanone is a highly reactive compound and is considered to be a strong electrophile, making it useful in various synthetic reactions. However, it is also toxic and can cause irritation to the skin, eyes, and respiratory system, and therefore should be handled with caution. Due to its reactivity and potential health hazards, 1-chlorobutanone is regulated and its use is restricted in some jurisdictions.
Uses
Used in Organic Synthesis:
1-Chlorobutanone is used as a chemical intermediate for the synthesis of various organic compounds. Its strong electrophilic nature makes it a versatile reagent in a wide range of synthetic reactions, including the formation of carbon-carbon bonds and the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Chemical Research:
1-Chlorobutanone is used as a reagent in chemical research to study the reactivity and selectivity of various organic reactions. Its ability to participate in a variety of synthetic transformations makes it a valuable tool for chemists in understanding reaction mechanisms and developing new synthetic methods.
Used in Pharmaceutical Industry:
1-Chlorobutanone is used as a building block in the synthesis of certain pharmaceutical compounds. Its reactivity allows for the formation of complex molecular structures that are difficult to access through other synthetic routes.
Used in Agrochemical Industry:
1-Chlorobutanone is used in the synthesis of agrochemicals, such as pesticides and herbicides. Its ability to form stable intermediates and participate in various synthetic reactions makes it a valuable component in the development of new and effective agrochemical products.
Used in Specialty Chemicals:
1-Chlorobutanone is used in the production of specialty chemicals, such as fragrances, dyes, and other fine chemicals. Its versatility as a reagent allows for the synthesis of a wide range of chemical products with unique properties and applications.
Check Digit Verification of cas no
The CAS Registry Mumber 616-27-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,1 and 6 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 616-27:
(5*6)+(4*1)+(3*6)+(2*2)+(1*7)=63
63 % 10 = 3
So 616-27-3 is a valid CAS Registry Number.
InChI:InChI=1/C4H7ClO/c1-2-4(6)3-5/h2-3H2,1H3
616-27-3Relevant articles and documents
A mild method for conversion of epoxides into α-chloro ketones
Raina,Bhuniya,Singh
, p. 6021 - 6022 (1992)
Epoxides on treatment with DMSO, oxalyl chloride, and 10 mole % of methanol in the presence of triethylamine at -60°C are converted to α-chloro ketones in high yield.
A mild method for the replacement of a hydroxyl group by halogen. 1. Scope and chemoselectivity
Munyemana, Fran?ois,George, Isabelle,Devos, Alain,Colens, Alain,Badarau, Eduard,Frisque-Hesbain, Anne-Marie,Loudet, Aurore,Differding, Edmond,Damien, Jean-Marie,Rémion, Jeanine,Van Uytbergen, Jacqueline,Ghosez, Léon
, p. 420 - 430 (2015/12/31)
α-Chloro-, bromo- and iodoenamines, which are readily prepared from the corresponding isobutyramides have been found to be excellent reagents for the transformation of a wide variety of alcohols or carboxylic acids into the corresponding halides. Yields are high and conditions are very mild thus allowing for the presence of sensitive functional groups. The reagents can be easily tuned allowing therefore the selective monohalogenation of polyhydroxylated molecules. The scope and chemoselectivity of the reactions have been studied and reaction mechanisms have been proposed.
Method for preparing chiral diphosphines
-
, (2008/06/13)
The invention concerns a method for preparing a compound of formula (1) wherein: A represents naphthyl or phenyl optionally substituted; and Ar1, Ar2independently represent a saturated or aromatic carbocyclic group, optionally substituted.
