7488-99-5 Usage
Description
Carotene is a group of organic compounds that includes α-carotene and β-carotene, which are precursors of vitamin A and are found in various fruits and vegetables. They are responsible for the yellow, orange, or red pigments in plants and animal tissues. Carotene is a terpenoid hydrocarbon and functions as a colorant and provitamin.
Uses
Used in Cosmetic Industry:
Carotene is used as a colorant to provide a red-orange color in cosmetic formulations.
Used in Food Industry:
Carotene is used as a natural colorant in ice cream, cheese, and other dairy products. It is also the primary yellow coloring component of butter, carrots, and egg yolk.
Used in Health and Nutrition:
Carotene is used as a vitamin A precursor, which is converted by the body to vitamin A. It has been found to inhibit the proliferation of GOTO human neuroblastoma cells and halt the cell cycle at the G0/G1 phase, reducing the mRNA expression of the protooncogene N-Myc. It is also more potent than β-carotene in mouse models of skin and lung carcinogenesis and decreases the number of hepatomas in mice with spontaneous liver carcinogenesis when administered in drinking water at a concentration of 0.05%. Additionally, α-carotene levels are increased in patients with coronary heart disease and are inversely correlated with the risk of estrogen receptor-negative breast cancer.
Biochem/physiol Actions
One of the primary isomers of carotene, enantiomerically pure form of metabolite in carotenoid biosynthesis, biosynthesis of plant secondary metabolites, biosynthesis of terpenoids and steroids and the biosynthesis of secondary metabolites.
Purification Methods
Purify α-carotene by chromatography on columns of calcium hydroxide, alumina or magnesia. Crystallise it from CS2/MeOH, toluene/MeOH, diethyl ether/pet ether, or acetone/pet ether. Store it in the dark, under N2 or Ar at -20o. It gives a blue colour with max at 542nm when mixed with SbCl3 in CHCl3. [Karrer & Walker Helv Chim Acta 16 641 1933, Eugster et al. Helv Chim Acta 52 1729 1969, Eugster & Karrer Helv Chim Acta 38 610 1955, Strain J Biol Chem 105 523 1934, Beilstein 5 III 2457, 5 IV 2620.]
Check Digit Verification of cas no
The CAS Registry Mumber 7488-99-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,4,8 and 8 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 7488-99:
(6*7)+(5*4)+(4*8)+(3*8)+(2*9)+(1*9)=145
145 % 10 = 5
So 7488-99-5 is a valid CAS Registry Number.
InChI:InChI=1/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-23,25-28,37H,15-16,24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+/t37-/m0/s1
7488-99-5Relevant articles and documents
Karrer,Eugster
, p. 1952 (1950)
Artificially coloring the skin with a carotene compound, a xanthophyll compound and a lipophilic green dye composition
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, (2010/06/22)
A method for artificially coloring the skin entails topical application thereon of a composition containing, formulated into a physiologically acceptable medium: a) at least one compound of the carotene type,b) at least one compound of the xanthophyll type,c) at least one lipophilic green dye; the composition advantageously includes a mixture of dyes including:a) at least one compound of the carotene type,b) at least astaxanthin,c) at least one lipophilic green dye.
Absolute configuration of xanthophyll (lutein)
Buchecker,Hamm,Eugster
, p. 631 - 656 (2007/10/07)
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