78277-26-6Relevant articles and documents
Neem PROTAC compound with STAT3 degradation activity and preparation method and application thereof
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Paragraph 0045; 0097-0099, (2022/01/10)
A NEEM PROTAC compound with STAT3 degradation activity, the structure of which is generally formula (I): Y is a specific protein ligand in the E3 ubiquitin ligase complex, a Cereblon protein ligand or A VHL protein ligand; X is a linking group between nee
MOLECULES THAT STIMULATE THE IMMUNE SYSTEM FOR TREATMENT OF DRUG ADDICTION, METHODS OF SYNTHESIS, ANTIDRUG VACCINE AND USES
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Paragraph 0033; 0143; 0168-0171, (2020/12/20)
This technology relates to immune system stimulating molecules to be used in the treatment of drug addiction and abuse and their synthesis processes. These molecules have a calixarene chemical structure, preferably calix[4]arene and/or calix[8]arene, coupled to an hapten analogous to cocaine, preferably GNE and/or GNC. An anti-drug vaccine, specifically anti-cocaine, is also described using such molecules. The anti-drug vaccine can be also used to prevent fetal exposure to drugs in pregnant women who use drugs and do not wish or cannot stop their use during pregnancy.
CATIONIC LIPID
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Paragraph 0148-0151, (2019/05/10)
The present invention provides a cationic lipid which is able to be used for nucleic acid delivery to the cytoplasm. A cationic lipid according to the present invention is, for example, a compound represented by formula (1a) or a pharmaceutically acceptable salt thereof. (In formula (1a), each of L1 and L2 independently represent an alkylene group having 3-10 carbon atoms; each of R1 and R2 independently represent an alkyl group having 4-22 carbon atoms or an alkenyl group having 4-22 carbon atoms; X1 represents a single bond or -CO-O-; and ring P represents one of formulae (P-1) to (P-5).)(In formulae (P-1) to (P-5), R3 represents an alkyl group having 1-3 carbon atoms.)