83654-05-1 Usage
Description
1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE is a chemical compound with the molecular formula C22H44N2O4. It is characterized by the presence of two cyclohexyloximinocarbonylamino groups attached to a hexane chain. 1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE has potential applications in various fields due to its unique structure and properties.
Uses
1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE is used as a selective inhibitor of DAG lipase for the inhibition of arachidonic acid production. This makes it a valuable tool in studying the role of DAG lipase in various biological processes and its potential as a therapeutic target for certain diseases.
Used in Pharmaceutical Industry:
1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE is used as a research compound for investigating the role of DAG lipase in the production of arachidonic acid, which is an important signaling molecule involved in various physiological and pathological processes. Understanding the function of DAG lipase and its inhibition by this compound can help in the development of new drugs targeting this enzyme for the treatment of related diseases.
Used in Research Applications:
1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE is used as a research tool in cell biology and molecular biology studies to investigate the role of DAG lipase in cellular processes. Its selective inhibition of DAG lipase activity allows researchers to study the effects of modulating this enzyme on various cellular functions and signaling pathways.
Biological Activity
Inhibitor of diacylglycerol lipase (IC 50 values are 1.1 and 4 μ M in rat cardiac myocytes and canine platelets respectively). Weakly inhibits phospholipases C and A 2 . Potentiates acetylcholine evoked relaxation in mesenteric arteries by the inhibition of cholinesterase activity (IC 50 = 4 μ M).
References
1) Southerland and Amin (1982), Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors; J. Biol. Chem., 257 14006
2) Rindlisbacher et al. (1990), Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis; J. Neurochem., 54 1247
3) Chandra Sekar et al. (1987), Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors; Arch. Biochem. Biophys., 256 509
4) Levasseur et al. (1984), Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis; Prostaglandins, 27 673
5) Natarajan et al. (1988), Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors; Biochem. Biophys. Res. Commun., 156 717
Check Digit Verification of cas no
The CAS Registry Mumber 83654-05-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,3,6,5 and 4 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 83654-05:
(7*8)+(6*3)+(5*6)+(4*5)+(3*4)+(2*0)+(1*5)=141
141 % 10 = 1
So 83654-05-1 is a valid CAS Registry Number.
InChI:InChI=1/C20H34N4O4/c25-19(27-23-17-11-5-3-6-12-17)21-15-9-1-2-10-16-22-20(26)28-24-18-13-7-4-8-14-18/h1-16H2,(H,21,25)(H,22,26)
