83935-42-6

Basic information

• Product Name: 1H-Pyrrole, 1-(2,4-dichlorophenyl)-2,5-dimethyl-
• CAS NO: 83935-42-6
• Molecular Formula: C12H11Cl2N
• Molecular Weight: 240.132
• Mol File: 83935-42-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole, 1-(2,4-dichlorophenyl)-2,5-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole, 1-(2,4-dichlorophenyl)-2,5-dimethyl-(83935-42-6)
• EPA Substance Registry System: 1H-Pyrrole, 1-(2,4-dichlorophenyl)-2,5-dimethyl-(83935-42-6)

Safety Data

• Hazardous Substances Data: 83935-42-6(Hazardous Substances Data)

Upstream product

• 554-00-7 2,4-Dichloroaniline 
• 110-13-4 2,5-hexanedione 

Downstream Products

• 138223-01-5 1-[1-(2,4-Dichloro-phenyl)-2,5-dimethyl-1H-pyrrol-3-ylmethyl]-piperidine 
• 138223-00-4 4-[1-(2,4-Dichloro-phenyl)-2,5-dimethyl-1H-pyrrol-3-ylmethyl]-morpholine 
• 138222-99-8 1-[1-(2,4-Dichloro-phenyl)-2,5-dimethyl-1H-pyrrol-3-ylmethyl]-4-methyl-piperazine 
• 138222-98-7 1-(2,4-dichlorophenyl)-2,5-dimethyl-3-(dimethylaminomethyl)-pyrrole 
• 138222-73-8 1-(2,4-dichlorophenyl)-2,5-dimethyl-3-formylpyrrole 
• 138222-76-1 [1-[1-(2,4-Dichloro-phenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-meth-(E)-ylidene]-phenyl-amine 
• 138223-02-6 [1-(2,4-Dichloro-phenyl)-2,5-dimethyl-1H-pyrrol-3-ylmethyl]-phenyl-amine 

Relevant articles and documents

Synthesis and biological evaluation of 2-(2-methyl-1H-pyrrol-3-yl)-2-oxo-N-(pyridine-3-yl) acetamide derivatives: in vitro α-glucosidase inhibition, and kinetic and molecular docking study

One of the therapeutic approaches in the management of type 2 diabetes is delaying the glucose absorption through α-glucosidase enzyme inhibition, which can reduce the occurrence of postprandial hyperglycemia. Based on this thought, a series of novel chloro-substituted 2-(2-methyl-1-phenyl-1H-pyrrol-3-yl)-2-oxo-N-(pyridin-3-yl) acetamide derivatives 5a–i were synthesized and their α-glucosidase inhibitory activities were evaluated. All the synthesized compounds have shown moderate to excellent in vitro α-glucosidase inhibitory activity with IC50 values in the range of 111–673?μM) as compared to acarbose, the standard drug (750 ± 9?μM). Compound 5e (111 ± 12?μM), among the series, was the most potent inhibitor of α-glucosidase in a competitive mode of action based on the kinetic study. The molecular docking study of compounds 5e and 5a revealed that they have a lower free binding energy (? 4.27?kcal/mol and ? 3.17?kcal/mol, respectively) than acarbose (? 2.47?kcal/mol), which indicates that the target compound binds more easily to the enzyme than acarbose does. The outcomes from the molecular docking studies supported the results obtained from the in vitro assay. In conclusion, the overall results of our study reveal that the synthesized compounds could be a potential candidate in the search for novel α-glucosidase inhibitors to manage postprandial hyperglycemia incidence.

Squaric acid catalyzed simple synthesis of N-substituted pyrroles in green reaction media

An operationally simple and efficient protocol for squaric acid catalyzed synthesis of N-substituted pyrroles via the reaction of 2,5- dimethoxytetrahydrofuran and 2,5-hexandione with aryl amines in green reaction media (water, deep eutectic solvent, and polyethylene glycol) under ultrasound irradiation or thermal conditions in good to excellent yields has been developed.

Research on antibacterial and antifungal agents

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