87205-99-0 Usage
Description
Dihydrotanshinone I is a bioactive compound derived from the traditional Chinese medicinal plant Salvia miltiorrhiza Bunge, commonly known as Danshen. It is a lipid-soluble component with a unique chemical structure that exhibits potent pharmacological properties, particularly in the realm of cancer therapy.
Uses
Used in Pharmaceutical Industry:
Dihydrotanshinone I is used as an anti-cancer agent for its ability to induce apoptosis in human colorectal cancer cells. This action contributes to the suppression of tumor growth and the prevention of cancer progression, making it a valuable component in the development of cancer treatments.
Additionally, Dihydrotanshinone I may be utilized in the formulation of drug delivery systems to enhance its bioavailability, targeting efficiency, and therapeutic effectiveness in cancer treatment. This application can potentially improve patient outcomes and response to treatment by ensuring that the compound reaches the intended site of action in the body.
Check Digit Verification of cas no
The CAS Registry Mumber 87205-99-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,7,2,0 and 5 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 87205-99:
(7*8)+(6*7)+(5*2)+(4*0)+(3*5)+(2*9)+(1*9)=150
150 % 10 = 0
So 87205-99-0 is a valid CAS Registry Number.
InChI:InChI=1S/C18H14O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-7,10H,8H2,1-2H3/t10-/m0/s1
87205-99-0Relevant articles and documents
Two new abietane diterpenoids from Salvia yunnanensis
Xu, Gang,Peng, Li-Yan,Lu, Lei,Weng, Zi-Ying,Zhao, Yu,Li, Xiao-Li,Zhao, Qin-Shi,Sun, Han-Dong
, p. 84 - 86 (2007/10/03)
Two new abietane diterpenoids, yunnannin A (1) and danshenol C (2), were isolated from Salvia yunnanensis together with ten known diterpenoids, danshenol A (3), przewalskin (4), tanshinone IIA, tanshinone I, crypotanshinone, 1,2-dihydrotanshinone, tanshinlactone, 5,6-dehydrosugiol, 12-hydroxy-6,7-seco-8, 11,3-abietatriene-6,7-dial and phytol. Their structures were established based on spectroscopic data, chemical reactions and comparison with literature data. Compounds 1-3 were tested for their antitumor activity in T-24, QGY, K562, Me180 and BIU87 cell lines. Compound 3 showed inhibited growth of K562 (IC 50 = 0.53 μg/mL), T-24 (IC50 = 7.94 μg/mL), QGY (IC50 = 4.65 μg/mL) and Me180 (IC50 = 6.89 μg/mL) cell lines while compound 2 was inactive. Compound 1 showed moderate inhibitory activity on QGY (IC50 = 16.75 μg/mL) and Me180 (IC50 = 5.84 μg/mL) cells. Georg Thieme Verlag KG Stuttgart.