952479-62-8

Basic information

• Product Name: methyl 2-phenyl-2H-indazole-7-carboxylate
• Synonyms: methyl 2-phenyl-2H-indazole-7-carboxylate
• CAS NO: 952479-62-8
• Molecular Weight: 252.272
• Mol File: 952479-62-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: methyl 2-phenyl-2H-indazole-7-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-phenyl-2H-indazole-7-carboxylate(952479-62-8)
• EPA Substance Registry System: methyl 2-phenyl-2H-indazole-7-carboxylate(952479-62-8)

Safety Data

• Hazardous Substances Data: 952479-62-8(Hazardous Substances Data)

Upstream product

• 132874-06-7 methyl 3-(bromomethyl)-2-nitrobenzoate 
• 5471-82-9 methyl 3-methyl-2-nitrobenzoate 
• 138229-59-1 3-formyl-2-nitrobenzoic acid methyl ester 
• 952479-61-7 methyl 2-nitro-3-[(phenylimino)methyl]benzoate 

Relevant articles and documents

PHARMACEUTICALLY ACCEPTABLE SALTS OF 2-{4-[(3S)-PIPERIDIN-3- YL]PHENYL} -2H-INDAZOLE-7-CARBOXAMIDE

The present invention relates to pharmaceutically acceptable salts of an amide substituted indazole which are inhibitors of the enzyme poly(ADP-ribose)polymerase (PARP), previously known as poly(ADP-ribose)synthase and poly(ADP-ribosyl)transferase. The compounds of the present invention are useful as mono-therapies in tumors with specific defects in DNA-repair pathways and as enhancers of certain DNA -damaging agents such as anticancer agents and radiotherapy. Further, the compounds of the present invention are useful for reducing cell necrosis (in stroke and myocardial infarction), down regulating inflammation and tissue injury, treating retroviral infections and protecting against the toxicity of chemotherapy.

AMIDE SUBSTITUTED INDAZOLE AND BENZOTRIAZOLE DERIVATIVES AS POLY(ADP-RIBOSE)POLYMERASE (PARP) INHIBITORS

The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly (ADP-ribose) polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusio