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Cas Database |
| Name |
1-Ethoxy-2,2-difluoroethanol |
EINECS | N/A | ||||||
| CAS No. | 148992-43-2 | Density | 1.145g/cm3 | ||||||
| PSA | 29.46000 | LogP | 0.60640 | ||||||
| Solubility | N/A | Melting Point |
N/A |
||||||
| Formula | C4H8 F2 O2 | Boiling Point | 85.1°C at 760 mmHg | ||||||
| Molecular Weight | 126.103 | Flash Point | 46.2°C | ||||||
| Transport Information | N/A | Appearance | N/A | ||||||
| Safety |
|
Risk Codes | 10 | ||||||
| Molecular Structure |
|
Hazard Symbols | N/A | ||||||
| Synonyms |
Difluoroacetaldehydeethyl hemiacetal |
Article Data | 16 |
1-Ethoxy-2,2-difluoroethanol Synthetic route
- 454-31-9
ethyl difluoroacetate
- 148992-43-2
1-ethoxy-2,2-difluoroethanol
| Conditions | Yield |
|---|---|
| With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at -78℃; for 2.75h; | 100% |
| With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at -78℃; for 3h; | 60% |
| With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at -78℃; for 3h; Reagent/catalyst; Solvent; | 60% |
| Conditions | Yield |
|---|---|
| With lithium aluminium tetrahydride 1.) Et2O, THF, -78 deg C, 3 h, 2.) Et2O, THF, rt, 2 h; |
| Conditions | Yield |
|---|---|
| With sodium tetrahydroborate; cerium(III) chloride In methanol; water at -15℃; for 1h; Title compound not separated from byproducts; | |
| With ruthenium(bis[2‐(ethylsulfanyl)ethyl]amine)(dichloro)(triphenylphosphine); hydrogen; sodium ethanolate In ethanol at 25℃; under 22502.3 Torr; for 4h; Reagent/catalyst; Solvent; Temperature; Pressure; |
- 433-53-4
difluoroacetic acid methyl ester
- 64-19-7
acetic acid
A
- 129660-32-8
difluoroacetaldehyde methyl hemiacetal
D
- 148992-43-2
1-ethoxy-2,2-difluoroethanol
| Conditions | Yield |
|---|---|
| Stage #1: difluoroacetic acid methyl ester With [carbonylchlorohydrido{bis[2-(diphenylphosphinomethyl)ethyl]amino}ethylamino] ruthenium(II); hydrogen; sodium methylate In methanol at 15℃; under 7500.75 Torr; for 8h; Large scale; Stage #2: acetic acid In methanol at 66℃; under 15.7516 Torr; Reagent/catalyst; Solvent; Pressure; Temperature; Large scale; |
- 454-31-9
ethyl difluoroacetate
A
- 359-13-7
difluoroethanol
B
- 129660-32-8
difluoroacetaldehyde methyl hemiacetal
C
- 148992-43-2
1-ethoxy-2,2-difluoroethanol
| Conditions | Yield |
|---|---|
| With [carbonylchlorohydrido{bis[2-(diphenylphosphinomethyl)ethyl]amino}ethylamino] ruthenium(II); hydrogen; sodium methylate In methanol at 15℃; under 7500.75 Torr; for 8.16667h; Pressure; |
- 106-42-3
para-xylene
- 148992-43-2
1-ethoxy-2,2-difluoroethanol
- 1314534-86-5
1,1-difluoro-2,2-bis(2',5'-dimethylphenyl)ethane
| Conditions | Yield |
|---|---|
| With boron trifluoride monohydrate In water at 0℃; for 0.5h; Friedel Crafts hydroxyalkylation; | 98% |
| Conditions | Yield |
|---|---|
| With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran | 96% |
| With potassium carbonate In tetrahydrofuran Ambient temperature; | 82% |
- 115306-75-7
3-(tertbutyldimethylsiloxyl)propylamine
- 148992-43-2
1-ethoxy-2,2-difluoroethanol
| Conditions | Yield |
|---|---|
| In benzene for 18h; Dean-Stark; Reflux; | 94% |
- 6456-74-2
Glycine tert-butyl ester
- 148992-43-2
1-ethoxy-2,2-difluoroethanol
| Conditions | Yield |
|---|---|
| In benzene for 18h; Dean-Stark; Reflux; | 93% |
| Conditions | Yield |
|---|---|
| at 50℃; for 24h; Sealed tube; Acidic conditions; | 93% |
1-Ethoxy-2,2-difluoroethanol Chemical Properties
Molecular Structure:
Molecular Formula: C4H8F2O2
Molecular Weight: 126.1019
Product Name: 1-Ethoxy-2,2-difluoroethanol
Synonyms of 1-Ethoxy-2,2-difluoroethanol (CAS NO.148992-43-2): Difluoroacetaldehyde ethyl hemiacetal
CAS NO: 148992-43-2
Product Categories: Fluorinated Building Blocks ; Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds ; Synthetic Organic Chemistry
Index of Refraction: 1.356
Molar Refractivity: 24.1 cm3
Molar Volume: 110 cm3
Surface Tension: 23.1 dyne/cm
Density: 1.145 g/cm3
Flash Point: 46.2 °C
Enthalpy of Vaporization: 37.95 kJ/mol
Boiling Point: 85.1 °C at 760 mmHg
Vapour Pressure of 1-Ethoxy-2,2-difluoroethanol (CAS NO.148992-43-2): 44.9 mmHg at 25°C
1-Ethoxy-2,2-difluoroethanol Safety Profile
Risk Statements of 1-Ethoxy-2,2-difluoroethanol (CAS NO.148992-43-2): 10
R10: Flammable.
Safety Statements: 16
S16: Keep away from sources of ignition.
RIDADR: 3271
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