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2-(Methylamino)pyridine

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Name

2-(Methylamino)pyridine

EINECS 224-997-9
CAS No. 4597-87-9 Density 1.059 g/cm3
PSA 24.92000 LogP 1.19630
Solubility N/A Melting Point 15 °C(lit.)
Formula C6H8N2 Boiling Point 201.3 °C at 760 mmHg
Molecular Weight 108.143 Flash Point 87.8 °C
Transport Information UN2810 Appearance N/A
Safety 26-36/37/39 Risk Codes 20/21/22-36/37/38
Molecular Structure Molecular Structure of 4597-87-9 (2-(Methylamino)pyridine) Hazard Symbols HarmfulXn
Synonyms

Pyridine,2-(methylamino)- (6CI,7CI,8CI);2-(Methylamino)pyridine;Methyl(pyridin-2-yl)amine;N-2-Pyridylmethylamine;N-Methyl-2-aminopyridine;N-Methyl-2-pyridinamine;N-Methyl-N-(2-pyridyl)amine;N-Methyl-N-(pyridin-2-yl)amine;NSC 122871;

Article Data 68

2-(Methylamino)pyridine Specification

The CAS register number of 2-(Methylamino)pyridine is 4597-87-9. It also can be called as Pyridine, 2-methylamino- and the systematic name about this chemical is N-methylpyridin-2-amine. The molecular formula about this chemical is C6H8N2 and the molecular weight is 108.14. It belongs to the following product categories which include C6; Heterocyclic Building Blocks; Pyridines and so on.

Physical properties about 2-(Methylamino)pyridine are: (1)ACD/LogP: 1.07; (2)ACD/LogD (pH 5.5): -0.46; (3)ACD/LogD (pH 7.4): 0.91; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 2.63; (6)ACD/KOC (pH 5.5): 2.71; (7)ACD/KOC (pH 7.4): 62.48; (8)#H bond acceptors: 2; (9)#H bond donors: 1; (10)Polar Surface Area: 16.13Å2; (11)Index of Refraction: 1.579; (12)Molar Refractivity: 33.95 cm3; (13)Molar Volume: 102.1 cm3; (14)Polarizability: 13.46x10-24cm3; (15)Surface Tension: 42.2 dyne/cm; (16)Enthalpy of Vaporization: 43.76 kJ/mol; (17)Boiling Point: 201.3 °C at 760 mmHg; (18)Vapour Pressure: 0.309 mmHg at 25°C.

Preparation: this chemical can be prepared by pyridin-2-ylamine and sulfuric acid dimethyl ester. This reaction will need reagent sodamide and solvent diethyl ether. The yield is about 60%.

Uses of 2-(Methylamino)pyridine: it can be used to produce methyl-nitroso-pyridin-2-yl-amine at temperature of 0 ℃. This reaction will need reagent hydrochloric acid and sodium nitrite.

When you are using this chemical, please be cautious about it as the following:
This chemical is harmful by inhalation, in contact with skin and if swallowed. It is irritating to eyes, respiratory system and skin. When you are using it, wear suitable protective clothing, gloves and eye/face protection. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: n1ccccc1NC
(2)InChI: InChI=1/C6H8N2/c1-7-6-4-2-3-5-8-6/h2-5H,1H3,(H,7,8)
(3)InChIKey: SVEUVITYHIHZQE-UHFFFAOYAB
(4)Std. InChI: InChI=1S/C6H8N2/c1-7-6-4-2-3-5-8-6/h2-5H,1H3,(H,7,8)
(5)Std. InChIKey: SVEUVITYHIHZQE-UHFFFAOYSA-N

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 270mg/kg (270mg/kg) BEHAVIORAL: EXCITEMENT Annales Pharmaceutiques Francaises. Vol. 26, Pg. 345, 1968.
 

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