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Name	2,12-DIHYDROXY-4-METHYL-11,16-DIOXOSENECIONANIUM	EINECS	N/A
CAS No.	2318-18-5	Density	1.22g/cm³
PSA	93.14000	LogP	0.94740
Solubility	N/A	Melting Point	197°C
Formula	C19H27 N O6	Boiling Point	604.9°Cat760mmHg
Molecular Weight	366.48	Flash Point	319.6°C
Transport Information	N/A	Appearance	N/A
Safety	Poison by ingestion and intraperitoneal routes. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x.	Risk Codes	22
Molecular Structure		Hazard Symbols	Xn
Synonyms	2,3,5,7a-Tetrahydro-1,7a-dihydroxy-7-(hydroxymethyl)-4-methyl-1H-pyrroliziniumhydroxide, inner salt, cyclic diester with senecic acid (7CI);4,8-Secosenecionan-8,11,16-trione, 12-hydroxy-4-methyl-;2,9-Dioxa-14-azabicyclo[9.5.1]heptadec-11-ene-3,8,17-trione,4-ethylidene-7-hydroxy-6,7,14-trimethyl-, [1R-(1R,4Z,6R,7R*)]-; NSC 89945;Renardin; Renardine; Renardine (neutral); Senkirkin; Senkirkine; Senkirkine(neutral)

2,12-DIHYDROXY-4-METHYL-11,16-DIOXOSENECIONANIUM Synthetic route

: 2318-18-5
(+)-senkirkine

: 67-68-5
dimethyl sulfoxide

: 61273-70-9
4-methyl-12-methylsulfanylmethoxy-4,8-seco-senecionane-8,11,16-trione

Conditions

Conditions	Yield
With acetic anhydride Ambient temperature;

: 2318-18-5
(+)-senkirkine

: 75-36-5
acetyl chloride

: 53092-44-7, 60872-63-1, 90364-91-3
acetylsenkirkine

2,12-DIHYDROXY-4-METHYL-11,16-DIOXOSENECIONANIUM Toxicity Data With Reference

1.	mma-sat 1 mg/plate	MUREAV Mutation Research. 68 (1979),211.
2.	sln-dmg-orl 10 µmol/L/3D-I	FCTOD7 Food and Chemical Toxicology. 22 (1984),223.
3.	dns-rat:lvr 2 µmol/L	CNREA8 Cancer Research. 45 (1985),3125.
4.	dns-mus:lvr 20 µmol/L	CNREA8 Cancer Research. 45 (1985),3125.
5.	dns-ham:lvr 2 µmol/L	CNREA8 Cancer Research. 45 (1985),3125.
6.	sce-ham:lng 60 µg/L	MUREAV Mutation Research. 142 (1985),209.
7.	orl-rat LDLo:200 mg/kg	NATUAS Nature. 227 (1970),401.
8.	ipr-rat LD50:220 mg/kg	JJIND8 JNCI, Journal of the National Cancer Institute. 63 (1979),469.

2,12-DIHYDROXY-4-METHYL-11,16-DIOXOSENECIONANIUM Consensus Reports

IARC Cancer Review: Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 31 ,1983,p. 231.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 10 ,1976,p. 327.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) .

2,12-DIHYDROXY-4-METHYL-11,16-DIOXOSENECIONANIUM Safety Profile

Poison by ingestion and intraperitoneal routes. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x.

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