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Basic Information
| CAS No.: | 2318-18-5 |
|---|---|
| Name: | SENKIRKIN |
| Molecular Structure: | |
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| Formula: | C19H27 N O6 |
| Molecular Weight: | 366.48 |
| Synonyms: | 2,3,5,7a-Tetrahydro-1,7a-dihydroxy-7-(hydroxymethyl)-4-methyl-1H-pyrroliziniumhydroxide, inner salt, cyclic diester with senecic acid (7CI);4,8-Secosenecionan-8,11,16-trione, 12-hydroxy-4-methyl-;2,9-Dioxa-14-azabicyclo[9.5.1]heptadec-11-ene-3,8,17-trione,4-ethylidene-7-hydroxy-6,7,14-trimethyl-, [1R-(1R*,4Z,6R*,7R*)]-; NSC 89945;Renardin; Renardine; Renardine (neutral); Senkirkin; Senkirkine; Senkirkine(neutral) |
| Density: | 1.22g/cm3 |
| Melting Point: | 197°C |
| Boiling Point: | 604.9°Cat760mmHg |
| Flash Point: | 319.6°C |
| Hazard Symbols: | Xn |
| Risk Codes: | 22 |
| Safety: | Poison by ingestion and intraperitoneal routes. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. |
| PSA: | 93.14000 |
| LogP: | 0.94740 |
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Synthetic route
- 2318-18-5
(+)-senkirkine
- 67-68-5
dimethyl sulfoxide
- 61273-70-9
4-methyl-12-methylsulfanylmethoxy-4,8-seco-senecionane-8,11,16-trione
Conditions
| Conditions | Yield |
|---|---|
| With acetic anhydride Ambient temperature; |
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SENKIRKIN
Toxicity Data With Reference
| 1. | mma-sat 1 mg/plate | MUREAV Mutation Research. 68 (1979),211. | ||
| 2. | sln-dmg-orl 10 µmol/L/3D-I | FCTOD7 Food and Chemical Toxicology. 22 (1984),223. | ||
| 3. | dns-rat:lvr 2 µmol/L | CNREA8 Cancer Research. 45 (1985),3125. | ||
| 4. | dns-mus:lvr 20 µmol/L | CNREA8 Cancer Research. 45 (1985),3125. | ||
| 5. | dns-ham:lvr 2 µmol/L | CNREA8 Cancer Research. 45 (1985),3125. | ||
| 6. | sce-ham:lng 60 µg/L | MUREAV Mutation Research. 142 (1985),209. | ||
| 7. | orl-rat LDLo:200 mg/kg | NATUAS Nature. 227 (1970),401. | ||
| 8. | ipr-rat LD50:220 mg/kg | JJIND8 JNCI, Journal of the National Cancer Institute. 63 (1979),469. |
Consensus Reports
IARC Cancer Review: Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 31 ,1983,p. 231.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 10 ,1976,p. 327.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) .
Safety Profile
Poison by ingestion and intraperitoneal routes. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.