- 2,3,4,5,6-Pentafluorobenzyl alcohol
- 2，3，4，5，6-Pentafluorobenzyl bromide
- 17654-68-11,2-Benzenedicarbonitrile,4-chloro-
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Cas Database |
| Name |
2，3，4，5，6-Pentafluorobenzyl bromide |
EINECS | 217-182-4 |
| CAS No. | 1765-40-8 | Density | 1.864 g/cm3 |
| PSA | 0.00000 | LogP | 3.27700 |
| Solubility | Hydrolyzes in water. | Melting Point |
19-20 °C(lit.) |
| Formula | C7H2BrF5 | Boiling Point | 173.2 °C at 760 mmHg |
| Molecular Weight | 260.989 | Flash Point | 82.8 °C |
| Transport Information | UN 3265 8/PG 2 | Appearance | Clear colourless to yellowish liquid |
| Safety | 26-36/37/39-45-23-27 | Risk Codes | 34-36/37/38-36/37 |
| Molecular Structure |
|
Hazard Symbols |
 Xi,  C
|
| Synonyms |
1-(Bromomethyl)pentafluorobenzene;2,3,4,5,6-Pentafluoro-a-bromotoluene;NSC 96888;Pentafluorobenzyl bromide;a-Bromo-2,3,4,5,6-pentafluorotoluene;Benzene,(bromomethyl)pentafluoro- (9CI);Toluene, a-bromo-2,3,4,5,6-pentafluoro- (6CI,7CI,8CI);(Bromomethyl)pentafluorobenzene;(Pentafluorophenyl)methyl bromide;1-(Bromomethyl)-2,3,4,5,6-pentafluorobenzene; |
Article Data | 10 |
2，3，4，5，6-Pentafluorobenzyl bromide Synthetic route
| Conditions | Yield |
|---|---|
| With N-Bromosuccinimide; potassium hexamethylsilazane; (1,3,4)-triphenyl-4,5-dihydro-1H-1,2,4-triazol-5-ylidene In dichloromethane at 20℃; for 6h; Appel Halogenation; Inert atmosphere; | 53% |
| With sulfuric acid; hydrogen bromide | |
| With hydrogen bromide |
- 118096-88-1
2,3,4,5,6-pentafluorobenzyl(dimethyl)sulphonium bromide
A
- 118096-90-5
3,4,5,6-tetrafluoro-2-methylthiomethylbenzyl bromide
B
- 118096-91-6
(E)-1-pentafluorophenyl-2-(3,4,5,6-tetrafluoro-2-methylthiomethyl)phenylethene
C
- 118096-92-7
1,2-bis(3,4,5,6-tetrafluoro-2-methylthiomethylphenyl)ethene
D
- 1765-40-8
(bromomethyl)pentafluorobenzene
| Conditions | Yield |
|---|---|
| With n-butyllithium In tetrahydrofuran; hexane at -70 - 20℃; for 19h; Mechanism; Product distribution; | A 2.5% B 5% C 11% D 32% |
| Conditions | Yield |
|---|---|
| With bromine In tetrachloromethane | |
| With bromine Irradiation; | |
| Multi-step reaction with 3 steps 1: Cl2 / Irradiation 2: aq. K2CO3 / Heating 3: aq. HBr, H2SO4 View Scheme | |
| With bromine at 36℃; for 18h; Irradiation; neat (no solvent); | |
| With N-Bromosuccinimide at 36℃; for 18.3333h; Reactivity; Time; Irradiation; neat (no solvent); |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: (i) Mg, (ii) /BRN= 636496/ 2: LiAlH4 3: aq. HBr, H2SO4 View Scheme |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: LiAlH4 2: aq. HBr, H2SO4 View Scheme |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: (i) Mg, (ii) /BRN= 906769/ 2: LiAlH4 3: aq. HBr, H2SO4 View Scheme |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: aq. K2CO3 / Heating 2: aq. HBr, H2SO4 View Scheme |
| Conditions | Yield |
|---|---|
| With N-Bromosuccinimide at 36℃; for 18h; Irradiation; neat (no solvent); |
- 603-35-0
triphenylphosphine
- 1765-40-8
(bromomethyl)pentafluorobenzene
- 13509-91-6
(2,3,4,5,6-pentafluorobenzyl)triphenylphosphonium bromide
| Conditions | Yield |
|---|---|
| In xylene at 115℃; for 18h; | 100% |
| In toluene Reflux; | 74% |
| In toluene for 1.5h; Heating; | 61% |
- 1765-40-8
(bromomethyl)pentafluorobenzene
- 594-09-2
trimethylphosphane
- 80431-31-8
Trimethyl<(pentafluorphenyl)methyl>phosphoniumbromid
| Conditions | Yield |
|---|---|
| In diethyl ether at 0℃; for 1h; | 100% |
2，3，4，5，6-Pentafluorobenzyl bromide Chemical Properties
Chemical Name: PENTAFLUOROBENZYL BROMIDE
IUPAC NAME: 1-(bromomethyl)-2,3,4,5,6-pentafluorobenzene
CAS No.: 1765-40-8
EINECS: 217-182-4
Molecular Formula: C7H2BrF5
Molecular Weight: 260.99 g/mol
Melting Point: 19-20 °C(lit.)
Density: 1.864 g/cm3
Flash Point: 82.8 °C
Boiling Point: 173.2 °C at 760 mmHg
Sensitive: Lachrymatory
Following is the structure of 2，3，4，5，6-Pentafluorobenzyl bromide (1765-40-8):
.gif)
Product Categories about 2，3，4，5，6-Pentafluorobenzyl bromide (1765-40-8) are Aromatic Halides (substituted) ; Analytical Chemistry ; Boronic Acid, etc. (GC Derivatizing Reagents) ; GC Derivatizing Reagents
The chemical synonymous of 2，3，4，5，6-Pentafluorobenzyl bromide (1765-40-8) are 1-(Bromomethyl)-2,3,4,5,6-pentafluorobenzene ; 1-Bromomethylpentafluorobenzene ; Toluene, alpha-bromo-2,3,4,5,6-pentafluoro- ; PFBBR ; PENTAFLUOROBENZYL BROMIDE ; PENTAFLUOROBROMOMETHYL BENZENE ; (BROMOMETHYL)PENTAFLUOROBENZENE ; 2,3,4,5,6-PENTAFLUOROBENZYL BROMIDE
2，3，4，5，6-Pentafluorobenzyl bromide Safety Profile
Hazard Note: Irritant/Lachrymatory
Hazard Codes:
C: Corrosive .gif){kind=small}
Xi: Irritant .gif){kind=small}
Risk Statements about 2，3，4，5，6-Pentafluorobenzyl bromide (1765-40-8):
R22 Harmful if swallowed.
R34 Causes burns.
R36/37: Irritating to eyes and respiratory system.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements about 2，3，4，5，6-Pentafluorobenzyl bromide (1765-40-8):
S23 Do not breathe vapour.
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S27 Take off immediately all contaminated clothing.
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection.
S45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
2，3，4，5，6-Pentafluorobenzyl bromide Specification
1. Storage: Keep away from sources of ignition. Store in a cool, dry place. Store in a tightly closed container. Corrosives area. Store under an inert atmosphere.
2. Handling: Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale. Use only in a chemical fume hood.
3. Personal Protection: Eyes: Wear chemical splash goggles.Skin: Wear chemical splash goggles. Wear appropriate protective gloves to prevent skin exposure.Clothing: Wear appropriate protective clothing to prevent skin exposure.Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
4. Fire Fighting: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Combustible liquid.Extinguishing Media: Use foam, dry chemical, or carbon dioxide. DO NOT USE WATER!
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