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2-Aminoindan hydrochloride

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Name

2-Aminoindan hydrochloride

EINECS 219-048-0
CAS No. 2338-18-3 Density 1.056 g/cm3
PSA 26.02000 LogP 2.61480
Solubility N/A Melting Point 245-247 °C(lit.)
Formula C9H12ClN Boiling Point 226.2 °C at 760 mmHg
Molecular Weight 169.654 Flash Point 96.8 °C
Transport Information N/A Appearance white solid
Safety 22-24/25 Risk Codes 22
Molecular Structure Molecular Structure of 2338-18-3 (1H-Inden-2-amine,2,3-dihydro-, hydrochloride (1:1)) Hazard Symbols HarmfulXn
Synonyms

1H-Inden-2-amine,2,3-dihydro-, hydrochloride (9CI);2-Indanamine, hydrochloride (8CI);(2,3-Dihydro-1H-inden-2-yl)amine hydrochloride;2,3-Dihydro-1H-inden-2-aminehydrochloride;2-Amino-2,3-dihydro-1H-indene hydrochloride;2-Aminoindanhydrochloride;2-Aminoindan monohydrochloride;Indan-2-ylamine hydrochloride;SU 8629 hydrochloride;

Article Data 7

2-Aminoindan hydrochloride Specification

The 2-Aminoindane hydrochloride, with the CAS registry number 2338-18-3, is also known as 1H-Inden-2-amine, 2,3-dihydro-, hydrochloride (9CI). Its EINECS registry number is 219-048-0. This chemical's molecular formula is C9H12ClN and molecular weight is 169.65. Its IUPAC name is called 2,3-dihydro-1H-inden-2-amine hydrochloride. This chemical's classification code is Drug / Therapeutic Agent. You should keep its container tightly closed in a cool, well-ventilated place. When you are using this chemical, please be cautious about it. This chemical may cause damage to health. It is harmful if swallowed. You should not breathe its dust. What's more, you must avoid contacting it with skin and eyes.

Physical properties of 2-Aminoindane hydrochloride: (1)ACD/LogP: 1.75; (2)ACD/LogD (pH 5.5): -1.25; (3)ACD/LogD (pH 7.4): -0.04; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 3.45; (8)#H bond acceptors: 1; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 1; (11)Flash Point: 96.8 °C; (12)Enthalpy of Vaporization: 46.27 kJ/mol; (13)Boiling Point: 226.2 °C at 760 mmHg; (14)Vapour Pressure: 0.0831 mmHg at 25°C.

Preparation: this chemical can be prepared by indan-2-one oxime. This reaction will need reagent H2, HCl and solvent ethanol. The reaction time is 8 hours. The yield is about 44%.

Uses of 2-Aminoindane hydrochloride: it can be used to produce 2-indanylbiguanide at temperature of 160 °C. This reaction is a kind of Addition. The reaction time is 100 min. The yield is about 58%.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: C1C(CC2=CC=CC=C21)N.Cl
(2)InChI: InChI=1S/C9H11N.ClH/c10-9-5-7-3-1-2-4-8(7)6-9;/h1-4,9H,5-6,10H2;1H
(3)InChIKey: XEHNLVMHWYPNEQ-UHFFFAOYSA-N

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo oral 50mg/kg (50mg/kg) BEHAVIORAL: ANALGESIA Journal of Pharmacology and Experimental Therapeutics. Vol. 133, Pg. 400, 1961.
mouse LD50 intraperitoneal 170mg/kg (170mg/kg) BEHAVIORAL: ANALGESIA Journal of Pharmacology and Experimental Therapeutics. Vol. 133, Pg. 400, 1961.
mouse LD50 oral 500mg/kg (500mg/kg) BEHAVIORAL: ANALGESIA Journal of Pharmacology and Experimental Therapeutics. Vol. 133, Pg. 400, 1961.
mouse LD50 subcutaneous 158mg/kg (158mg/kg) BEHAVIORAL: ANALGESIA Journal of Pharmacology and Experimental Therapeutics. Vol. 133, Pg. 400, 1961.
rat LD50 intravenous 36300ug/kg (36.3mg/kg)   Psychopharmacology Service Center, Bulletin. Vol. 2, Pg. 17, 1963.
rat LD50 oral 326mg/kg (326mg/kg)   Psychopharmacology Service Center, Bulletin. Vol. 2, Pg. 17, 1963.