- 2-Chloro-1-(2,3,4,5,6-pentamethylphenyl)ethanone
- 2-Chloro-1-(2,5-dichlorophenyl)ethanone
- 2-Chloro-1-(2,5-dimethoxyphenyl)ethanone
- 2-Chloro-1-(2-methoxyphenyl)ethanone
- 2-Chloro-1-(2-methyl-1H-indol-3-yl)ethanone
- 2-CHLORO-1-(2-METHYLAMINOPROPYL)-3,5,7-TRIMETHYLADAMANTANE HYDRO-CHLORIDE
- 2-Chloro-1-(3,4-difluoro-phenyl)-ethanone
- 2-Chloro-1-(4-chlorophenyl)-2,2-difluoro-ethanone
- 2-Chloro-1-(4-ethoxyphenyl)ethanone
- 2-Chloro-1-(4-fluorophenyl)ethanol
- 82241-22-3Quinoline, 2-methyl-4-(1-piperazinyl)-
- 82-24-62-Anthracenecarboxylicacid, 1-amino-9,10-dihydro-9,10-dioxo-
- 82248-59-7Benzenepropanamine,N-methyl-g-(2-methylphenoxy)-,hydrochloride (1:1), (gR)-
- 82248-68-82,5-Furandione,3-(1-ethyl-2-buten-1-yl)dihydro-
- 82249-98-7Heat-labileenterotoxin, (Escherichia coli subunit A reduced) (9CI)
- 822-50-4Cyclopentane,1,2-dimethyl-, (1R,2R)-rel-
- 82252-39-9Boc-Leu-(?)-Val-OH
- 822-55-91H-Imidazole-5-methanol
- 82257-09-8Pyridine,3-bromo-4-methoxy-
- 82257-15-63-Pyridinecarboxaldehyde,4-methoxy-
Hot Products
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin
- 7631-86-9Silicon dioxide
- 302-79-4Tretinoin
- 77-92-9Citric acid
|
Basic Information |
|
Post buying leads |
|
Suppliers |
|
Cas Database |
| Name |
2-Chloro-1,3,2-dioxaphospholane |
EINECS | 212-499-4 |
| CAS No. | 822-39-9 | Density | 1.422 |
| PSA | 32.05000 | LogP | 1.49890 |
| Solubility | N/A | Melting Point |
-28oC |
| Formula | C2H4 Cl O2 P | Boiling Point | 117.4 °C at 760 mmHg 62 oC (20 mmHg) |
| Molecular Weight | 126.479 | Flash Point | 86 ºC |
| Transport Information | UN 3264 | Appearance | clear colorless to slightly yellow liquid |
| Safety | S25;S8 | Risk Codes | R14;R34 |
| Molecular Structure |
|
Hazard Symbols |
|
| Synonyms |
Ethylenephosphorochloridite (6CI,7CI); Phosphorochloridous acid, cyclic ethylene ester(8CI); Ethylene glycol, cyclic phosphorochloridite (8CI);2-Chloro-1,3,2-dioxaphospholane; Cyclic O,O-ethylene phosphorochloridite;Cyclic ethylene chlorophosphite; Cyclic ethylene phosphorochloridite; Ethylenechlorophosphite; Ethylene glycol chlorophosphite |
Article Data | 38 |
2-Chloro-1,3,2-dioxaphospholane Synthetic route
| Conditions | Yield |
|---|---|
| With phosphorus trichloride In dichloromethane at 0℃; for 14h; | 92% |
| With phosphorus trichloride In dichloromethane at 20℃; for 0.5h; Inert atmosphere; | 74.7% |
| With phosphorus trichloride In dichloromethane at 20℃; for 3h; Inert atmosphere; | 67% |
- 107-21-1
ethylene glycol
A
- 37445-80-0
1,1,6,6-tetrachloro-2,5-dioxa-1,6-diphosphahexane
B
- 822-39-9
2-chloro-1,3,2-dioxaphospholan
| Conditions | Yield |
|---|---|
| With triethylamine; phosphorus trichloride at 45℃; Reagent/catalyst; | A 51.7% B n/a |
| With phosphorus trichloride anfangs unter Luehlung,dann bei 60-70grad; |
- 18882-67-2
2-methyl-[1,3,2]dioxarsolane
- 822-39-9
2-chloro-1,3,2-dioxaphospholan
| Conditions | Yield |
|---|---|
| With phosphorus trichloride In benzene |
- 110-86-1
pyridine
- 60-29-7
diethyl ether
- 107-21-1
ethylene glycol
- 7719-12-2, 52843-90-0
phosphorus trichloride
- 822-39-9
2-chloro-1,3,2-dioxaphospholan
- 75-09-2
dichloromethane
- 107-21-1
ethylene glycol
- 7719-12-2, 52843-90-0
phosphorus trichloride
- 822-39-9
2-chloro-1,3,2-dioxaphospholan
- 60-29-7
diethyl ether
- 107-21-1
ethylene glycol
- 121-69-7
N,N-dimethyl-aniline
- 7719-12-2, 52843-90-0
phosphorus trichloride
- 822-39-9
2-chloro-1,3,2-dioxaphospholan
- 107-21-1
ethylene glycol
- 7719-12-2, 52843-90-0
phosphorus trichloride
A
- 37445-80-0
1,1,6,6-tetrachloro-2,5-dioxa-1,6-diphosphahexane
B
- 822-39-9
2-chloro-1,3,2-dioxaphospholan
| Conditions | Yield |
|---|---|
| anfangs unter Kuehlung, dann bei 60-70grad; |
- 822-39-9
2-chloro-1,3,2-dioxaphospholan
- 85741-80-6
2-azido-1,3,2-dioxaphospholane
| Conditions | Yield |
|---|---|
| With trimethylsilylazide at 0 - 5℃; for 3h; | 100% |
| With (C2H5)3N*NH3 |
- 88070-48-8
N-methylbenzamide
- 822-39-9
2-chloro-1,3,2-dioxaphospholan
| Conditions | Yield |
|---|---|
| In diethyl ether Ambient temperature; | 97% |
- 127472-90-6
2,3-Di(stearoyloxy)-1-propanthiol
- 822-39-9
2-chloro-1,3,2-dioxaphospholan
- 134152-76-4
2-(2,3-Distearoyloxypropyl)-1,3,2-dioxaphospholan-2-sulfid
| Conditions | Yield |
|---|---|
| With triethylamine In benzene for 3h; Ambient temperature; | 96% |
2-Chloro-1,3,2-dioxaphospholane Chemical Properties
IUPAC Name: 2-Chloro-1,3,2-dioxaphospholane
Synonyms of 1,3,2-Dioxaphospholane,2-chloro- (CAS NO.822-39-9): 2-Chloro-1,3,2-dioxaphospholane ; Ethylene chlorophosphite ; Ethylene glycol chlorophosphite
CAS NO: 822-39-9
Molecular Formula: C2H4ClO2P
Molecular Weight: 126.48
Molecular Structure: 
EINECS: 212-499-4
H bond acceptors: 2
H bond donors: 0
Freely Rotating Bonds: 0
Polar Surface Area: 32.05 Å2
Flash Point: 24.8 °C
Enthalpy of Vaporization: 34.09 kJ/mol
Boiling Point: 117.4 °C at 760 mmHg
Vapour Pressure: 20.8 mmHg at 25°C
Storage temp: 2-8°C
Sensitive: Moisture Sensitive
Appearance: Clear Colourless Oil
SMILES: ClP1OCCO1
InChI: InChI=1/C2H4ClO2P/c3-6-4-1-2-5-6/h1-2H2
InChIKey: OLSFRDLMFAOSIA-UHFFFAOYAF
Std. InChI: InChI=1S/C2H4ClO2P/c3-6-4-1-2-5-6/h1-2H2
Std. InChIKey: OLSFRDLMFAOSIA-UHFFFAOYSA-N
Product Categories of 1,3,2-Dioxaphospholane,2-chloro- (CAS NO.822-39-9): Biochemistry;Nucleosides, Nucleotides & Related Reagents;Phosphorylating and Phosphorothioating Agents;Phosphorylation;Protecting Agents, Phosphorylating Agents & Condensing Agents;Synthetic Organic Chemistry;Phosphorylating and Phosphitylating Agents
2-Chloro-1,3,2-dioxaphospholane Uses
1,3,2-Dioxaphospholane,2-chloro- (CAS NO.822-39-9) is used as highly reactive cyclic phosphitylating reagent which provides fast coupling rates, and hydrolytic cleavage occurs more readily than with acyclic analogs.
2-Chloro-1,3,2-dioxaphospholane Safety Profile
Hazard Codes: 
C
Risk Statements: 14-34-37
R14 : Reacts violently with water.
R34: Causes burns.
R37: Irritating to respiratory system
Safety Statements: 8-25-26-36/37/39-45
S8: Keep container dry.
S25: Avoid contact with eyes.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 3264 8/PG 2
WGK Germany: 3
F: 1-10
HazardClass: 8
PackingGroup: II
2-Chloro-1,3,2-dioxaphospholane Specification
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Water Reactive. Combustible liquid.
Extinguishing Media: Do NOT use water directly on fire. Use foam, dry chemical, or carbon dioxide.
Handling: Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.
Storage: Keep 1,3,2-Dioxaphospholane,2-chloro- (CAS NO.822-39-9) away from sources of ignition. Store in a cool, dry place. Store in a tightly closed container. Keep under a nitrogen blanket. Keep refrigerated. (Store below 4°C/39°F.)
What can I do for you?
Get Best Price
