2-Chloro-1,3,2-dioxaphospholane

Base Information

• Chemical Name: 2-Chloro-1,3,2-dioxaphospholane
• CAS No.: 822-39-9
• Deprecated CAS: 103613-07-6
• Molecular Formula: C2H4 Cl O2 P
• Molecular Weight: 126.479
• European Community (EC) Number: 212-499-4
• DSSTox Substance ID: DTXSID4061173
• Nikkaji Number: J26.475J
• Wikidata: Q72449684
• Mol file: 822-39-9.mol

Synonyms:2-Chloro-1,3,2-dioxaphospholane;822-39-9;Ethylene chlorophosphite;1,3,2-Dioxaphospholane, 2-chloro-;EINECS 212-499-4;C2H4ClO2P;Ethylene phosphorochloridite;Ethylene cyclo-Chlorophosphite;SCHEMBL5849;Cyclic ethylene chlorophosphite;C2-H4-Cl-O2-P;DTXSID4061173;Cyclic ethylene phosphorochloridite;MFCD00014511;AKOS015912770;2-Chloro-1,3,2-dioxaphospholane, 97%;FT-0626288;D89371;Ethylenephosphorochloridite(2-chloro-1,3,2-dioxaphospholane)

Chemical Property of 2-Chloro-1,3,2-dioxaphospholane

Chemical Property:

• Appearance/Colour: clear colorless to slightly yellow liquid
• Vapor Pressure: 20.8mmHg at 25°C
• Melting Point: -28oC
• Refractive Index: n20/D 1.489(lit.)
• Boiling Point: 117.4 °C at 760 mmHg 62 oC (20 mmHg)
• Flash Point: 86 ºC
• PSA: 32.05000
• Density: 1.422
• LogP: 1.49890
• Storage Temp.: 2-8°C
• Sensitive.: Moisture Sensitive
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 125.9637441
• Heavy Atom Count: 6
• Complexity: 44.8

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-1,3,2-dioxaphospholane ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C
• Statements: 14-34-37
• Safety Statements: 26-36/37/39-45-8-25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1COP(O1)Cl
• Uses: Ethylene chlorophosphite acts as a phosphitylating agent involved in the preparation of phosphocholine and spirophosphoranes. For example, it is used in the phosphorylation of p-tert-butyl(thia)calixarenes.

Technology Process of 2-Chloro-1,3,2-dioxaphospholane

There total 8 articles about 2-Chloro-1,3,2-dioxaphospholane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

ethylene glycol (107-21-1) → 2-chloro-1,3,2-dioxaphospholan (822-39-9)

Guidance literature:

With phosphorus trichloride; In dichloromethane; at 0 ℃; for 14h;

Reference yield: 69.1%

→ 2-chloro-1,3,2-dioxaphospholan (822-39-9)

Guidance literature:

Reference yield: 51.7%

ethylene glycol (107-21-1) → 1,1,6,6-tetrachloro-2,5-dioxa-1,6-diphosphahexane (37445-80-0) + 2-chloro-1,3,2-dioxaphospholan (822-39-9)

Guidance literature:

With triethylamine; phosphorus trichloride; at 45 ℃; Reagent/catalyst;

upstream raw materials:

ethylene glycol

2-methyl-[1,3,2]dioxarsolane

pyridine

diethyl ether

Downstream raw materials:

2-(Cyclohex-1-enyloxy)-[1,3,2]dioxaphospholane

2-Chloro-2-oxo-1,3,2-dioxaphospholane

2-chloroethyl phosphorodichloridate

2-Benzyloxy-1,3,2-dioxaphospholan

Refernces

• 1、 -. "Phosphine ligand compound and preparation method thereof, catalyst composition and application thereof and vinyl acetate hydroformylation method (by machine translation)". Paragraph 0077-0080. . Retrieved 2020/07/13.
• 2、 -. "Phosphine ligand compound and preparation method thereof, catalyst composition and application thereof and vinyl acetate hydroformylation method (by machine translation)". Paragraph 0079-0082. . Retrieved 2020/07/13.