Hot Products

Basic Information

Post buying leads

Suppliers

Cas Database

Name	2-Pyrrolidinecarboxamide,1-(2-chloroacetyl)-, (2S)-	EINECS	1308068-626-2
CAS No.	214398-99-9	Density	1.353±0.06 g/cm3(Predicted)
PSA	63.40000	LogP	0.33970
Solubility	N/A	Melting Point	133-137℃ (isopropyl ether )
Formula	C₇H₁₁ClN₂O₂	Boiling Point	442.5±45.0 °C(Predicted)
Molecular Weight	190.63	Flash Point	N/A
Transport Information	N/A	Appearance	N/A
Safety		Risk Codes	N/A
Molecular Structure		Hazard Symbols	N/A
Synonyms	2-Pyrrolidinecarboxamide,1-(chloroacetyl)-, (2S)- (9CI);	Article Data	39

2-Pyrrolidinecarboxamide,1-(2-chloroacetyl)-, (2S)- Synthetic route

: 23500-10-9
(S)-1-(2-chloroacetyl)pyrrolidine-2-carboxylic acid

: 214398-99-9
(S)-1-(2-chloroacetyl) pyrrolidine-2-carboxamide

Conditions

Conditions	Yield
With pyridine; di-tert-butyl dicarbonate; ammonium bicarbonate In acetonitrile at 20℃; for 1.5h; Inert atmosphere;	84%
With pyridine; di-tert-butyl dicarbonate; ammonium bicarbonate In acetonitrile at 25℃; for 1.5h;	84%
Stage #1: (S)-1-(2-chloroacetyl)pyrrolidine-2-carboxylic acid With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 5h; Cooling with ice; Stage #2: With ammonium carbamate In dichloromethane at 20℃; for 6h;	71.2%

: 79-04-9
chloroacetyl chloride

: 7531-52-4
L-prolinamide

: 214398-99-9
(S)-1-(2-chloroacetyl) pyrrolidine-2-carboxamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 5℃; for 2h; Reagent/catalyst; Inert atmosphere;	96%
With triethylamine In dichloromethane at -5 - 0℃; for 0.5h; Inert atmosphere;	96.3%
In tetrahydrofuran at 0℃; Reflux; Large scale;	92%

: C7H9Cl2NO2

: 214398-99-9
(S)-1-(2-chloroacetyl) pyrrolidine-2-carboxamide

Conditions

Conditions	Yield
With ammonia In dichloromethane for 2h;

: 147-85-3
L-proline

: 214398-99-9
(S)-1-(2-chloroacetyl) pyrrolidine-2-carboxamide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: chloro-trimethyl-silane / acetonitrile / 1 h / 50 °C 1.2: 20 °C 2.1: thionyl chloride / dichloromethane / 1.17 h / 0 - 20 °C 2.2: 2 h View Scheme
Multi-step reaction with 2 steps 1.1: tetrahydrofuran / 2.5 h / 65 - 70 °C 2.1: dicyclohexyl-carbodiimide / dichloromethane / 1 h / 0 - 30 °C 2.2: 3 h / 25 - 30 °C View Scheme
Multi-step reaction with 2 steps 1.1: tetrahydrofuran / 3 h / Reflux 2.1: dicyclohexyl-carbodiimide / dichloromethane / 5 h / 20 °C / Cooling with ice 2.2: 6 h / 20 °C View Scheme

: 2577-48-2
methyl (2S)-pyrrolidine carboxylate

: 214398-99-9
(S)-1-(2-chloroacetyl) pyrrolidine-2-carboxamide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: ammonium hydroxide 2: tetrahydrofuran View Scheme
Multi-step reaction with 2 steps 1: ammonium hydroxide / butan-1-ol / 5 - 30 °C 2: N,N-dimethyl-formamide / -5 - 25 °C / Inert atmosphere View Scheme

: 214398-99-9
(S)-1-(2-chloroacetyl) pyrrolidine-2-carboxamide

: 565452-98-4
(S)-1-(2-chloroacetyl)-2-cyanopyrrolidine

Conditions

Conditions	Yield
With 1,3,5-trichloro-2,4,6-triazine In N,N-dimethyl-formamide at 0℃; Large scale;	90%

: 214398-99-9
(S)-1-(2-chloroacetyl) pyrrolidine-2-carboxamide

: 96166-39-1
1-glycoloyl-L-proline amide

Conditions

Conditions	Yield
With sodium carbonate In acetone at 50℃; for 5h; Temperature;	93%

: 214398-99-9
(S)-1-(2-chloroacetyl) pyrrolidine-2-carboxamide

: 207557-35-5
(S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile

Conditions

Conditions	Yield
With palladium(II) trifluoroacetate; dichloroacetonitrile; water In acetonitrile at 60℃; for 2h; Catalytic behavior; Temperature; Reagent/catalyst; Solvent; Concentration; Schlenk technique; Inert atmosphere;	95%
With 1,3,5-trichloro-2,4,6-triazine In N,N-dimethyl-formamide at 35 - 48℃; for 4h;	90%
With 1,3,5-trichloro-2,4,6-triazine In N,N-dimethyl-formamide at 40℃; for 4h;	90%

: 214398-99-9
(S)-1-(2-chloroacetyl) pyrrolidine-2-carboxamide

: 1262802-99-2
(S)-1-(2-chloroacetyl)pyrrolidin-2-carboxamide hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In water; isopropyl alcohol at 70℃;

: 8-(5-nitropyridin-2-yl)-8-azabicyclo[3.2.1]oct-3-yl-exo-amine

: 214398-99-9
(S)-1-(2-chloroacetyl) pyrrolidine-2-carboxamide

: (2S)-1-(2-{[8-(5-nitropyridin-2-yl)-8-azabicyclo[3.2.1]oct-3-yl]exo-amino}acetyl)pyrrolidine-2-carbonitrile

Conditions

Conditions	Yield
With 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine In acetonitrile	41%

2-Pyrrolidinecarboxamide,1-(2-chloroacetyl)-, (2S)- Chemical Properties

Product Name: 2-Pyrrolidinecarboxamide,1-(2-chloroacetyl)-, (2S)- (CAS NO.214398-99-9)
Molecular Formula: C₇H₁₁ClN₂O₂
Mol File: 214398-99-9.mol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 214398-99-9