- 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
- 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
- 632356-42-44-Chloro-3-thiophenamine
- 632365-54-91H-Pyrazole-3-carboxylicacid,5-amino-,methylester(9CI)
- 63237-84-3Pyrazolo[1,5-a]pyridine-3-carboxylic acid methyl ester
- 63237-87-6Pyrazolo[1,5-a]pyridine-2,3-dicarboxylicacid
- 63237-88-7Pyrazolo[1,5-a]pyridine-2-carboxylicacid
- 6323-82-62-Butyn-1-amine,N,N-diethyl-
- 6323-97-3Phosphonic acid,P-(1-aminoethyl)-
- 6324-10-32-Thiophenecarboxylicacid, 4,5-dibromo-
- 6324-11-4Acetic acid,2-(2-hydroxyphenoxy)-
- 6324-20-5N-(3-acetamido-2,4,6-trimethyl-phenyl)acetamide
Hot Products
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin
- 7631-86-9Silicon dioxide
- 302-79-4Tretinoin
- 77-92-9Citric acid
|
Basic Information |
|
Post buying leads |
|
Suppliers |
|
Cas Database |
| Name |
3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one |
EINECS | 613-192-1 |
| CAS No. | 63234-80-0 | Density | 1.3 g/cm3 |
| PSA | 34.89000 | LogP | 1.66930 |
| Solubility | N/A | Melting Point |
68.5-69.5 °C |
| Formula | C11H15ClN2O | Boiling Point | 336.6 °C at 760 mmHg |
| Molecular Weight | 226.706 | Flash Point | 157.4 °C |
| Transport Information | N/A | Appearance | White solid |
| Safety | 45 | Risk Codes | 25 |
| Molecular Structure |
|
Hazard Symbols | T |
| Synonyms |
3-(2-Chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one;3-(2-Chloroethyl)-6,7,8,9-Tetrahydro-2-Methyl-4h-Pyrido(1,2a)Pyrimidine-4-One; |
Article Data | 7 |
3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one Synthetic route
- 41078-70-0
3-(2-chloro-ethyl)-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
- 63234-80-0
3-(2-chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
| Conditions | Yield |
|---|---|
| With hydrogenchloride; hydrogen; palladium In water at 20℃; under 1810.07 Torr; for 8h; | 90% |
| With hydrogenchloride; palladium on activated charcoal; hydrogen In water at 30 - 40℃; under 1500.15 Torr; Temperature; Reagent/catalyst; | 90% |
| With palladium on activated charcoal; hydrogen In ethanol under 760.051 Torr; for 20h; | 47% |
| With palladium 10% on activated carbon; hydrogen In methanol | 4.6 g |
| With palladium 10% on activated carbon; hydrogen In methanol |
- 63234-80-0
3-(2-chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
| Conditions | Yield |
|---|---|
| With sodium carbonate; potassium iodide In water; 4-methyl-2-pentanone Product distribution / selectivity; |
- 504-29-0
2-aminopyridine
- 63234-80-0
3-(2-chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: toluene-4-sulfonic acid / toluene / Reflux 2: trichlorophosphate / 1 h / Reflux 3: palladium 10% on activated carbon; hydrogen / methanol View Scheme | |
| Multi-step reaction with 3 steps 1: toluene-4-sulfonic acid / toluene / 12 h / Reflux; Dean-Stark 2: trichlorophosphate / 1 h / Reflux 3: hydrogen; palladium 10% on activated carbon / methanol View Scheme | |
| Multi-step reaction with 2 steps 1: trichlorophosphate / toluene / 6 h / Reflux 2: palladium on activated charcoal; hydrogen / ethanol / 20 h / 760.05 Torr View Scheme |
- 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran
- 63234-80-0
3-(2-chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: toluene-4-sulfonic acid / toluene / Reflux 2: trichlorophosphate / 1 h / Reflux 3: palladium 10% on activated carbon; hydrogen / methanol View Scheme | |
| Multi-step reaction with 3 steps 1: toluene-4-sulfonic acid / toluene / 12 h / Reflux; Dean-Stark 2: trichlorophosphate / 1 h / Reflux 3: hydrogen; palladium 10% on activated carbon / methanol View Scheme | |
| Multi-step reaction with 2 steps 1: trichlorophosphate / toluene / 6 h / Reflux 2: palladium on activated charcoal; hydrogen / ethanol / 20 h / 760.05 Torr View Scheme |
- 380634-63-9
3-(1-(pyridin-2-ylamino)ethylidene)dihydrofuran-2-(3H)-one
- 63234-80-0
3-(2-chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: trichlorophosphate / 1 h / Reflux 2: palladium 10% on activated carbon; hydrogen / methanol View Scheme | |
| Multi-step reaction with 2 steps 1: trichlorophosphate / 1 h / Reflux 2: hydrogen; palladium 10% on activated carbon / methanol View Scheme |
- 63234-80-0
3-(2-chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
| Conditions | Yield |
|---|---|
| With palladium 10% on activated carbon; hydrogen In methanol; dichloromethane |
- 773837-37-9
sodium cyanide
- 63234-80-0
3-(2-chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
| Conditions | Yield |
|---|---|
| at 20℃; for 5h; | 100% |
- 63234-80-0
3-(2-chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
- 1235992-87-6
3-{2-[4-(4-bromo-1-methyl-1H-pyrazole-3-carbonyl)piperazin-1-yl]ethyl}-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
| Conditions | Yield |
|---|---|
| With potassium carbonate In acetonitrile at 150℃; for 0.333333h; Microwave irradiation; | 99% |
- 63234-80-0
3-(2-chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
- 84163-13-3
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
- 106266-06-2
Risperidone
| Conditions | Yield |
|---|---|
| With sodium carbonate In water at 110 - 120℃; for 0.666667h; Product distribution / selectivity; | 93.2% |
| With sodium carbonate; potassium iodide In N,N-dimethyl-formamide at 80℃; for 10h; Temperature; | 76.9% |
- 63234-80-0
3-(2-chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
- 84163-77-9
6-fluoro-3-(4-piperidinyl)benzo[d]isoxazole
- 106266-06-2
Risperidone
| Conditions | Yield |
|---|---|
| With sodium carbonate In methanol at 73 - 75℃; for 4 - 4.5h; Product distribution / selectivity; | 92.8% |
| With N-ethyl-N,N-diisopropylamine In methanol at 45 - 50℃; for 70 - 100h; Product distribution / selectivity; | 77.8% |
| With sodium carbonate In water at 85 - 90℃; for 4h; | 73% |
| With potassium iodide; sodium carbonate In water; isopropyl alcohol |
3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one Specification
The systematic name of this chemical is 3-(2-chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one. With the CAS registry number 63234-80-0, it is also named as 4H-Pyrido[1,2-a]pyrimidin-4-one, 3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-. The product's categories are nucleotides and nucleosides; bases & related reagents; intermediates & fine chemicals; nucleotides; pharmaceuticals. It is white solid which is used as an intermediate in the synthesis of Risperidone. Additionally, this chemical must be sealed in the container and placed in the cool and dry aera.
The other characteristics of this product can be summarized as: (1)ACD/LogP: 1.62; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.62; (4)ACD/LogD (pH 7.4): 1.62; (5)ACD/BCF (pH 5.5): 9.97; (6)ACD/BCF (pH 7.4): 10.09; (7)ACD/KOC (pH 5.5): 179.94; (8)ACD/KOC (pH 7.4): 182.03; (9)#H bond acceptors: 3; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 2; (12)Index of Refraction: 1.611; (13)Molar Refractivity: 60.41 cm3; (14)Molar Volume: 173.8 cm3; (15)Polarizability: 23.95×10-24 cm3; (16)Surface Tension: 44.9 dyne/cm; (17)Flash Point: 157.4 °C; (18)Enthalpy of Vaporization: 57.98 kJ/mol; (19)Boiling Point: 336.6 °C at 760 mmHg; (20)Vapour Pressure: 0.000111 mmHg at 25°C.
People can use the following data to convert to the molecule structure.
1. SMILES:O=C1/C(=C(\N=C2/N1CCCC2)C)CCCl
2. InChI:InChI=1/C11H15ClN2O/c1-8-9(5-6-12)11(15)14-7-3-2-4-10(14)13-8/h2-7H2,1H3
What can I do for you?
Get Best Price
