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3'-Amino-2'-hydroxyacetophenone
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Name

3'-Amino-2'-hydroxyacetophenone

 EINECS 676-239-5
CAS No. 70977-72-9 Density 1.242 g/cm3
PSA 63.32000 LogP 1.75820
Solubility N/A Melting Point 95-96 °C
Formula C8H9NO2 Boiling Point 287.2 °C at 760 mmHg
Molecular Weight 151.165 Flash Point 127.5 °C
Transport Information N/A Appearance N/A
Safety Risk Codes N/A
Molecular Structure Molecular Structure of 70977-72-9 (3-Amino-2-hydroxyacetophenone) Hazard Symbols N/A
Synonyms

Acetophenone,3'-amino-2'-hydroxy- (7CI);1-(3-Amino-2-hydroxyphenyl)ethanone;2-Acetyl-6-aminophenol;3-Amino-2-hydroxyacetophenone;

Article Data 12

3'-Amino-2'-hydroxyacetophenone Synthetic route

70977-85-4

1-(2-hydroxy-3-amino-5-bromophenyl)ethan-1-one

70977-72-9

3'-Amino-2'-hydroxyacetophenone

Conditions
ConditionsYield
With palladium on activated charcoal; hydrogen In ethanol under 15001.5 Torr; for 8h; Reflux; Large scale;91%
123687-02-5

3-acetamido-4-acetoxybenzenesulfonic acid

70977-72-9

3'-Amino-2'-hydroxyacetophenone

Conditions
ConditionsYield
Stage #1: 3-acetamido-4-acetoxybenzenesulfonic acid With aluminum (III) chloride In nitrobenzene for 5h; Reflux;
Stage #2: With hydrogenchloride In water at 20℃; for 6h; pH=9 - 10; Cooling with ice; Reflux;		87%
Stage #1: 3-acetamido-4-acetoxybenzenesulfonic acid With aluminum (III) chloride In chloroform for 5h; Reflux;
Stage #2: With hydrogenchloride In chloroform; water at 20℃; for 6h; Reflux;		87%
5467-64-1

2-acetamidophenyl acetate

70977-72-9

3'-Amino-2'-hydroxyacetophenone

Conditions
ConditionsYield
With titanium tetrachloride In 1-methyl-pyrrolidin-2-one at 120℃; for 3h; Catalytic behavior; Concentration; Fries Phenol Ester Rearrangement; Large scale;87%
28177-69-7

2-hydroxy-3-nitroacetophenone

70977-72-9

3'-Amino-2'-hydroxyacetophenone

Conditions
ConditionsYield
With hydrogenchloride; tin(ll) chloride
In diethyl ether; ethanol
With hydrogenchloride; tin In water; ethyl acetate Heating / reflux;
With hydrogenchloride; tin
70978-54-0

5'-bromo-2'-hydroxy-3'-nitroacetophenone

70977-72-9

3'-Amino-2'-hydroxyacetophenone

Conditions
ConditionsYield
In methanol; dichloromethane
614-80-2

2-(acetylamino)phenol

70977-72-9

3'-Amino-2'-hydroxyacetophenone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: N-Bromosuccinimide / dichloromethane / 3 h / 0 - 20 °C / Large scale
2: zinc(II) chloride; hydrogenchloride / acetonitrile / 20 h / 50 °C / Large scale
3: palladium on activated charcoal; hydrogen / ethanol / 8 h / 15001.5 Torr / Reflux; Large scale
View Scheme
95-55-6

2-amino-phenol

70977-72-9

3'-Amino-2'-hydroxyacetophenone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: water / 2 h / 20 °C / Cooling with ice; Large scale
2: N-Bromosuccinimide / dichloromethane / 3 h / 0 - 20 °C / Large scale
3: zinc(II) chloride; hydrogenchloride / acetonitrile / 20 h / 50 °C / Large scale
4: palladium on activated charcoal; hydrogen / ethanol / 8 h / 15001.5 Torr / Reflux; Large scale
View Scheme
3582-05-6

trifluoromethyl trifluoromethanesulfonate

70977-72-9

3'-Amino-2'-hydroxyacetophenone

7-acetylbenzo[d]oxazol-2(3H)-one

Conditions
ConditionsYield
In acetonitrile at 20℃; for 1h; Sealed tube;99%
30131-16-9

4-(4-phenyl-1-butoxy)benzoic acid

70977-72-9

3'-Amino-2'-hydroxyacetophenone

136450-06-1

3-[4-(4-phenyl-1-butoxy)benzoyl]amino-2-hydroxyacetophenone

Conditions
ConditionsYield
With phosphotungstic acid at 140℃; for 8h; Temperature; Time; Inert atmosphere;98.36%
Stage #1: 4-(4-phenyl-1-butoxy)benzoic acid With thionyl chloride at 50℃; for 3h;
Stage #2: 3'-Amino-2'-hydroxyacetophenone With pyridine In dichloromethane at 10℃; for 2h; Inert atmosphere;		84%

2-(benzyloxymethyl)benzofuran-5-carboxylic acid

70977-72-9

3'-Amino-2'-hydroxyacetophenone

N-(3-acetyl-2-hydroxyphenyl)-2-(benzyloxymethyl)benzofuran-5-carboxamide

Conditions
ConditionsYield
98%

3'-Amino-2'-hydroxyacetophenone Chemical Properties

IUPAC Name: 1-(3-Amino-2-hydroxyphenyl)ethanone 
Following is the structure of Ethanone,1-(3-amino-2-hydroxyphenyl)- (CAS NO.70977-72-9):
                      
Empirical Formula: C8H9NO2
Molecular Weight: 151.1626
Index of Refraction: 1.613
Molar Refractivity: 42.39 cm3
Molar Volume: 121.6 cm3
Density: 1.242 g/cm3
Flash Point: 127.5 °C
Polarizability: 16.8 10-24cm3
Surface Tension: 56.3 dyne/cm 
Enthalpy of Vaporization: 54.74 kJ/mol
Boiling Point: 287.2 °C at 760 mmHg
Vapour Pressure of Ethanone,1-(3-amino-2-hydroxyphenyl)- (CAS NO.70977-72-9): 0.00146 mmHg at 25 °C 
Product Categories of Ethanone,1-(3-amino-2-hydroxyphenyl)- (CAS NO.70977-72-9): ACETYLGROUP; (intermediate of pranlukast)
Canonical SMILES: CC(=O)C1=C(C(=CC=C1)N)O
InChI: InChI=1S/C8H9NO2/c1-5(10)6-3-2-4-7(9)8(6)11/h2-4,11H,9H2,1H3
InChIKey: NLLYXOVHEQVWJF-UHFFFAOYSA-N

3'-Amino-2'-hydroxyacetophenone Specification

 Ethanone,1-(3-amino-2-hydroxyphenyl)- , its cas register number 70977-72-9. It also can be called 3-Amino-2-hydroxyacetophenone ; and 2'-Hydroxy-3'-aminoacetophenone .

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