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3-Amino-2-picoline
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Name

3-Amino-2-picoline

 EINECS -0
CAS No. 3430-10-2 Density 1.068 g/cm3
PSA 38.91000 LogP 1.55340
Solubility N/A Melting Point 114-119 °C
Formula C6H8N2 Boiling Point 236.846 °C at 760 mmHg
Molecular Weight 108.143 Flash Point 120.083 °C
Transport Information UN 2811 Appearance Off-white crystal
Safety 26-36/39-45-36/37/39-36-27 Risk Codes 22-37/38-41-36/37/38-34
Molecular Structure Molecular Structure of 3430-10-2 (3-Amino-2-picoline) Hazard Symbols IrritantXi, ToxicT, HarmfulXn, CorrosiveC
Synonyms

2-Picoline,3-amino- (7CI,8CI);(2-Methylpyridin-3-yl)amine;2-Methyl-3-aminopyridine;2-Methyl-3-pyridinamine;3-Amino-2-methylpyridine;

Article Data 21

3-Amino-2-picoline Synthetic route

76809-24-0

2,2-dimethyl-3-(2-methylpyrid-3-yl)-4-oxo-4H-1,3-benzoxazine

A

3430-10-2

2-methyl-3-pyridinamine

B

69-72-7

salicylic acid

Conditions
ConditionsYield
With hydrogenchloride for 3h; Heating;A 93%
B n/a
18699-87-1

2-methyl-3-nitropyridine

3430-10-2

2-methyl-3-pyridinamine

Conditions
ConditionsYield
With iron; acetic acid for 2h; Heating;90%
With hydrogen; triethylamine; palladium 10% on activated carbon In methanol at 20℃; under 760.051 Torr; for 6h;
80352-63-2

3-aminopyridine-2-acetic acid

3430-10-2

2-methyl-3-pyridinamine

Conditions
ConditionsYield
In ethanol for 5h; Heating;86%
22280-60-0

6-chloro-4-methyl-3-nitropyridine

3430-10-2

2-methyl-3-pyridinamine

Conditions
ConditionsYield
With palladium on carbon; hydrogen66%
With methanol; Lindlar's catalyst Hydrogenation;
With methanol; palladium on activated charcoal Hydrogenation;
With sulfuric acid; zinc
1260000-13-2

2-methyl-3-pyridyl tosylate

3430-10-2

2-methyl-3-pyridinamine

Conditions
ConditionsYield
Stage #1: 2-methyl-3-pyridyl tosylate With [(k2-P,N-di(1-adamantyl)-2-morpholinophenylphosphine)Pd(Ph)Cl]; sodium t-butanolate In 1,4-dioxane Inert atmosphere; Glovebox;
Stage #2: With ammonia In 1,4-dioxane at 24℃; Inert atmosphere; Glovebox;		46%
6298-19-7

2-chloro-3-aminopyridine

13061-96-6

dihydroxy-methyl-borane

3430-10-2

2-methyl-3-pyridinamine

Conditions
ConditionsYield
With potassium carbonate; tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane for 120h; Suzuki reaction; Heating;35%
3430-10-2

2-methyl-3-pyridinamine

16019-33-3

2-(4,6-dichloropyrimidin-5-yl)acetaldehyde

1001398-59-9

N-[2-(4,6-dichloro-5-pyrimidinyl)ethyl]-2-methyl-3-pyridinamine

Conditions
ConditionsYield
Stage #1: 2-methyl-3-pyridinamine With trifluoroacetic acid at -15℃; for 0.5h;
Stage #2: With sodium tris(acetoxy)borohydride for 0.5h;
Stage #3: 2-(4,6-dichloropyrimidin-5-yl)acetaldehyde With water; sodium hydrogencarbonate more than 3 stages;		100%
With sodium cyanoborohydride; acetic acid In methanol at -15 - 20℃; for 19h;
3430-10-2

2-methyl-3-pyridinamine

(7aSR,11aSR)-9-oxo-11a-(2,2,2-trifluoro-ethyl)-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid

(7aSR,11aSR)-9-oxo-11a-(2,2,2-trifluoro-ethyl)-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid (2-methyl-pyridin-3-yl)-amide

Conditions
ConditionsYield
Stage #1: (7aSR,11aSR)-9-oxo-11a-(2,2,2-trifluoro-ethyl)-6,7,7a,8,9,10,11,11a-octahydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid With N-ethyl-N,N-diisopropylamine; fluoro-N,N,N′,N′-bis(tetramethylene)formamidinium hexafluorophosphate In tetrahydrofuran for 0.333333h;
Stage #2: 2-methyl-3-pyridinamine In tetrahydrofuran at 20 - 60℃; for 77h;		100%
3430-10-2

2-methyl-3-pyridinamine

(7aSR,11aRS)-methyl 11a-ethyl-7,7a,8,10,11,11a-hexahydro-6H-spiro[dibenzo[b,d]oxepine-9,2'-[1.3]dioxolane]-3-carboxylate

(7aSR,11aRS)-11a-ethyl-N-(2-methylpyridin-3-yl)-7,7a,8,10,11,11a-hexahydro-6H-spiro[dibenzo[b,d]oxepine-9,2'-[1.3]dioxolane]-3-carboxamide

Conditions
ConditionsYield
With lithium hexamethyldisilazane In tetrahydrofuran; toluene at 0℃; for 0.25h;100%
3430-10-2

2-methyl-3-pyridinamine

C21H26O4

C26H30N2O3

Conditions
ConditionsYield
With lithium hexamethyldisilazane In tetrahydrofuran; toluene at 20℃; for 0.0833333h;100%

3-Amino-2-picoline Specification

The 3-Amino-2-picoline with cas registry number of 3430-10-2 is a kind of compounds of pyridine. It is also known as 3-Amino-2-methylpyridine. Both its systematic name and IUPAC name are the same which is called 2-methylpyridin-3-amine. It also has the appearance of off-white crystal.

The physical properties about this chemical are: (1)ACD/LogP: 0.09; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 7.4): 0.062; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 4.639; (7)ACD/KOC (pH 7.4): 25.064; (8)#H bond acceptors: 2; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 1; (11)Index of Refraction: 1.574; (12)Molar Refractivity: 33.405 cm3; (13)Molar Volume: 101.213 cm3; (14)Surface Tension: 46.924 dyne/cm; (15)Density: 1.068 g/cm3; (16)Flash Point: 120.083 °C; (17)Enthalpy of Vaporization: 47.366 kJ/mol; (18)Boiling Point: 236.846 °C at 760 mmHg; (19)Vapour Pressure: 0.046 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
This chemical is harmful if swallowed and irritating to eyes, respiratory system and skin. It also causes burns. Therefore, it is better to wear suitable protective clothing, gloves and eye/face protection. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. After using it, take off immediately all contaminated clothing.

You can still convert the following datas into molecular structure:
(1)SMILES: Cc1c(cccn1)N;
(2)InChI: InChI=1/C6H8N2/c1-5-6(7)3-2-4-8-5/h2-4H,7H2,1H3;
(3)InChIKey: ZSFPJJJRNUZCEV-UHFFFAOYAD

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