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3-Chlorophenylhydrazine hydrochloride

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Name

3-Chlorophenylhydrazine hydrochloride

EINECS 219-005-6
CAS No. 2312-23-4 Density N/A
PSA 38.05000 LogP 3.20090
Solubility Soluble in water Melting Point 240-245 °C (dec.)(lit.)
Formula C6H7ClN2.HCl Boiling Point 266 °C at 760 mmHg
Molecular Weight 179.049 Flash Point 114.7 °C
Transport Information N/A Appearance white to light yellow crystal powder
Safety 26-37/39 Risk Codes 20/21/22
Molecular Structure Molecular Structure of 2312-23-4 (3-Chlorophenylhydrazine hydrochloride) Hazard Symbols HarmfulXn
Synonyms

Hydrazine,(3-chlorophenyl)-, monohydrochloride (9CI);Hydrazine, (m-chlorophenyl)-,hydrochloride (6CI,8CI);(3-Chlorophenyl)hydrazine monohydrochloride;3-Chlorophenylhydrazine hydrochloride;N-(3-Chlorophenyl)hydrazinehydrochloride;m-Chlorophenylhydrazine hydrochloride;

Article Data 10

3-Chlorophenylhydrazine hydrochloride Synthetic route

108-37-2

1-bromo-3-chlorobenzene

2312-23-4

m-chlorophenylhydrazine hydrochloride

Conditions
ConditionsYield
Stage #1: 1-bromo-3-chlorobenzene With potassium phosphate; copper(l) iodide; N,N′-bis(2,6-dimethylphenyl)oxalamide; cetyltrimethylammonim bromide In water at 80℃; for 0.25h; Schlenk technique; Inert atmosphere; Sealed tube;
Stage #2: With hydrazine hydrate In water at 80℃; Inert atmosphere; Schlenk technique; Sealed tube;
Stage #3: With hydrogenchloride In water pH=3 - 4; Inert atmosphere; Schlenk technique; Sealed tube;
82%
108-42-9

3-chloro-aniline

2312-23-4

m-chlorophenylhydrazine hydrochloride

Conditions
ConditionsYield
With diazotizing agent; tin(ll) chloride Multistep reaction;
Stage #1: 3-chloro-aniline With hydrogenchloride; sodium nitrite at 0℃;
Stage #2: With hydrogenchloride; tin(ll) chloride at 0℃; for 1h;
Stage #1: 3-chloro-aniline With hydrogenchloride; sodium nitrite In water for 0.333333h; Cooling with ice;
Stage #2: With hydrogenchloride; tin(II) chloride dihdyrate In water at -10 - -5℃; for 2h;
121-73-3

3-Chloronitrobenzene

2312-23-4

m-chlorophenylhydrazine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: Fe; aq. NH4Cl / 48 h / Heating
2.1: NaNO2; aq. HCl / 0 °C
2.2: SnCl2; aq. HCl / 1 h / 0 °C
View Scheme
2312-23-4

m-chlorophenylhydrazine hydrochloride

82874-96-2

2-methoxyimino-4-oxo-pentaneperoxoic acid ethyl ester

709654-29-5

ethyl 1-(3-chlorophenyl)-3-methyl-1H-pyrazole-5-carboxylate

Conditions
ConditionsYield
In ethanol for 5h; Heating;99%
2312-23-4

m-chlorophenylhydrazine hydrochloride

335151-67-2

3-benzoyl-4-hydroxy-1-phenylquinolin-2(1H)-one

1-(3-chlorophenyl)-3,5-diphenyl-1H-pyrazolo[4,3-c]quinolin-4(5H)-one

Conditions
ConditionsYield
With sulfuric acid In acetic acid for 2h; Heating;98%
958462-15-2

(3E)-1-benzoyl-3-(dimethylamino)methylidenepyrrolidin-2-one

2312-23-4

m-chlorophenylhydrazine hydrochloride

958462-28-7

N-{2-[1-(3-chlorophenyl)-5-hydroxy-1H-pyrazol-4-yl]ethyl}benzamide

Conditions
ConditionsYield
In propan-1-ol for 4h; Heating;97%
2312-23-4

m-chlorophenylhydrazine hydrochloride

1-(3-chlorophenyl)-8-{1-[2-(3-chlorophenyl)hydrazono]ethyl}-5,7-dihydroxy-3,4a,6-trimethyl-1H-[1]benzofuro[3,2-f]indazol-4(4aH)-one

Conditions
ConditionsYield
With pyridine In ethanol for 2h; Reflux;95%
600-22-6

pyruvic acid methyl ester

2312-23-4

m-chlorophenylhydrazine hydrochloride

1609930-28-0

C10H11ClN2O2

Conditions
ConditionsYield
In methanol Reflux;95%
2312-23-4

m-chlorophenylhydrazine hydrochloride

potassium salt of 2-formyldimedone

308248-83-1

2-(3-chlorophenylhydrazinomethylene)-5,5-dimethyl-1,3-cyclohexandione

Conditions
ConditionsYield
In water at 80 - 90℃; Condensation;94%
2312-23-4

m-chlorophenylhydrazine hydrochloride

17823-69-7

2-cyano-3,3-bis(methylthio)acrylamide

5-amino-4-carboxamido-1-(3-chlorophenyl)-3-(methylthio)pyrazole

Conditions
ConditionsYield
With triethylamine In methanol Heating;94%

3-Chlorophenylhydrazine hydrochloride Specification

The Hydrazine,(3-chlorophenyl)-, hydrochloride (1:1), with the CAS registry number 2312-23-4 and EINECS registry number 219-005-6, has the the systematic name and IUPAC name of (3-chlorophenyl)hydrazine hydrochloride (1:1). It is a kind of white to light yellow crystal powder, and belongs to the following product categories: Amines and Anilines; Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes; Phenylhydrazine; Hydrazines; Nitrogen Compounds; Organic Building Blocks. And the molecular formula of the chemical is C6H7ClN2.HCl.

The characteristics of Hydrazine,(3-chlorophenyl)-, hydrochloride (1:1) are as followings: (1)ACD/LogP: 2.28; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.18; (4)ACD/LogD (pH 7.4): 2.28; (5)ACD/BCF (pH 5.5): 25.11; (6)ACD/BCF (pH 7.4): 31.72; (7)ACD/KOC (pH 5.5): 326.86; (8)ACD/KOC (pH 7.4): 412.95; (9)#H bond acceptors: 2; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 6.48 Å2 ; (13)Flash Point: 114.7 °C; (14)Enthalpy of Vaporization: 50.4 kJ/mol; (15)Boiling Point: 266 °C at 760 mmHg; (16)Vapour Pressure: 0.00887 mmHg at 25°C.

Uses of Hydrazine,(3-chlorophenyl)-, hydrochloride (1:1): It can react with 1,1,3,3-tetraethoxy-propane to produce 1-(3-chlorophenyl)-1H-pyrazole. This reaction will need reagent ethanol. The reaction time is 0.5 hours with heating, and the yield is about 69%.  

You should be cautious while dealing with this chemical. It is harmful by inhalation, in contact with skin and if swallowed. Therefore, you had better take the following instructions: Wear suitable gloves and eye/face protection, and if in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

Addtionally, the following datas could be converted into the molecular structure:
(1)SMILES: Clc1cc(NN)ccc1.Cl
(2)InChI: InChI=1/C6H7ClN2.ClH/c7-5-2-1-3-6(4-5)9-8;/h1-4,9H,8H2;1H
(3)InChIKey: CRRIAWUJYMLJOE-UHFFFAOYAK

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