- 4-(2-Chloroethyl)morpholine
- 4-(2-Chloroethyl)morpholine hydrochloride
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Cas Database |
| Name |
4-(2-Chloroethyl)morpholine hydrochloride |
EINECS | 222-881-2 |
| CAS No. | 3647-69-6 | Density | 1.088g/cm3 |
| PSA | 12.47000 | LogP | 1.29730 |
| Solubility | Soluble in water | Melting Point |
180-185 °C (dec.)(lit.) |
| Formula | C6H12ClNO.HCl | Boiling Point | 202.8 °C at 760 mmHg |
| Molecular Weight | 186.081 | Flash Point | 76.4 °C |
| Transport Information | UN 2923 8/PG 3 | Appearance | White to beige crystalline powder |
| Safety | 26-36/37/39-45-61 | Risk Codes | 21-25-34-43-52/53 |
| Molecular Structure |
|
Hazard Symbols |
 T
|
| Synonyms |
Morpholine,4-(2-chloroethyl)-, hydrochloride (6CI,7CI,8CI,9CI);1-(Morpholin-4-yl)-2-chloroethane hydrochloride;1-Chloro-2-morpholinoethanehydrochloride;2-(4-Morpholinyl)ethyl chloride hydrochloride;2-Morpholinoethylchloride hydrochloride;4-(2-Chloroethyl)morpholine monohydrochloride;4-(2-Chloroethyl)morpholiniumchloride;Morpholinoethyl chloride hydrochloride;N-(2-Chloroethyl)morpholinehydrochloride;N-(b-Chloroethyl)morpholine hydrochloride;b-Morpholinoethyl chloride hydrochloride; |
Article Data | 5 |
4-(2-Chloroethyl)morpholine hydrochloride Synthetic route
B
- 3647-69-6
4-(2-chloroethyl)morpholine hydrochride
B
- 3647-69-6
4-(2-chloroethyl)morpholine hydrochride
B
- 3647-69-6
4-(2-chloroethyl)morpholine hydrochride
| Conditions | Yield |
|---|---|
| With thionyl chloride; sodium hydroxide In toluene for 5h; Reflux; | |
| Stage #1: morpholine; 2-chloro-ethanol In toluene for 2h; Reflux; Stage #2: With thionyl chloride In toluene at 20℃; for 6.33h; Cooling with ice; | 7.9 g |
| Conditions | Yield |
|---|---|
| With thionyl chloride In chloroform Reflux; Cooling with ice; |
- 3647-69-6
4-(2-chloroethyl)morpholine hydrochride
| Conditions | Yield |
|---|---|
| With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 18h; | 100% |
- 3647-69-6
4-(2-chloroethyl)morpholine hydrochride
| Conditions | Yield |
|---|---|
| With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 18h; | 100% |
- 55289-05-9
methyl 3-hydroxy-2-methylbenzoate
- 3647-69-6
4-(2-chloroethyl)morpholine hydrochride
- 467252-57-9
methyl 2-methyl-3-(2-morpholinoethoxy)benzoate
| Conditions | Yield |
|---|---|
| With potassium carbonate In acetonitrile Heating; | 100% |
- 3647-69-6
4-(2-chloroethyl)morpholine hydrochride
- 99-76-3
methyl 4-hydroxylbenzoate
- 92501-87-6
methyl 4-(2-morpholinoethoxy)benzoate
| Conditions | Yield |
|---|---|
| With potassium carbonate In acetonitrile at 50℃; | 100% |
| With caesium carbonate In acetonitrile at 80 - 85℃; for 4h; Inert atmosphere; | 92% |
| With potassium carbonate In acetone Heating; |
- 15174-02-4
4-hydroxy-2-nitroanisole
- 3647-69-6
4-(2-chloroethyl)morpholine hydrochride
- 761440-70-4
4-[2-(4-methoxy-3-nitro-phenoxy)-ethyl]-morpholine
| Conditions | Yield |
|---|---|
| With potassium carbonate; potassium iodide In DMF (N,N-dimethyl-formamide) at 80℃; for 4h; | 100% |
4-(2-Chloroethyl)morpholine hydrochloride Chemical Properties
Molecular Formula: C6H13Cl2NO 
Formula Weight: 186.08
mp OF 4-(2-CHLOROETHYL)MORPHOLINE HYDRO CHLORIDE (3647-69-6): 180-185 °C (dec.)(lit.)
Flash Point: 76.4 °C
Boiling Point: 202.8 °C at 760 mmHg
Water Solubility : soluble
Vapour Pressure: 0.288 mmHg at 25°C
Sensitive of 4-(2-CHLOROETHYL)MORPHOLINE HYDRO CHLORIDE (3647-69-6): Hygroscopic
Appearence of 4-(2-CHLOROETHYL)MORPHOLINE HYDRO CHLORIDE (3647-69-6): White to beige crystalline powder
4-(2-Chloroethyl)morpholine hydrochloride Uses
4-(2-Chloroethyl)morpholine hydro chloride (3647-69-6) (MOC) is used as intermediate for the synthesis of pharmaceuticals (e.g. floredil, morinamide, nimorazole and pholcodine).
4-(2-Chloroethyl)morpholine hydrochloride Production
4-(2-Chloroethyl)morpholine hydro chloride (3647-69-6) is obtained by thionyl chloride chlorination reaction with morpholine ethanol, which is get from the addition reaction of morpholine and epoxy ethane.
4-(2-Chloroethyl)morpholine hydrochloride Toxicity Data With Reference
| 1. | mmo-sat 21,500 nmol/L | ENMUDM Environmental Mutagenesis. 3 (1981),11. | ||
| 2. | mmo-esc 21,500 nmol/L | ENMUDM Environmental Mutagenesis. 3 (1981),11. | ||
| 3. | dns-rat:lvr 100 µmol/L | ENMUDM Environmental Mutagenesis. 3 (1981),11. | ||
| 4. | msc-mus:lym 44 µmol/L | ENMUDM Environmental Mutagenesis. 3 (1981),33. |
4-(2-Chloroethyl)morpholine hydrochloride Consensus Reports
4-(2-Chloroethyl)morpholine hydrochloride Safety Profile
Safety: WARNING: Irreversible damage risk, protect skin/eyes/lungs.
Hazard Codes : T (Toxic)
Risk Statements : 21-25-34-43-52/53 (Harmful in contact with skin; Toxic if swallowed; Causes burns; May cause sensitization by skin contact; Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment)
Safety Statements : 26-36/37/39-45-61 (In case of contact with eyes, rinse immediately with plenty of water and seek medical advice; Wear suitable protective clothing, gloves and eye/face protection; In case of accident or if you feel unwell, seek medical advice immediately; Avoid release to the environment. Refer to special instructions safety data sheet)
RIDADR : UN 2923 8/PG 3
WGK Germany : 2
RTECS : QE0260000
PackingGroup : III
HS Code : 29349990
Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cl− and NOx.
4-(2-Chloroethyl)morpholine hydrochloride Specification
Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep container closed when not in use.
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