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Name	4-Ethyl-2,3-dioxo-1-piperazine carbonyl chloride	EINECS	261-867-0
CAS No.	59703-00-3	Density	1.408 g/cm³
PSA	57.69000	LogP	-0.08830
Solubility	decomposes	Melting Point	100 °C
Formula	C₇H₉ClN₂O₃	Boiling Point	292.9 °C at 760 mmHg
Molecular Weight	204.613	Flash Point	131 °C
Transport Information	N/A	Appearance	White to tan powder, partially agglomerated
Safety	45-36/37/39-26	Risk Codes	34
Molecular Structure		Hazard Symbols	C
Synonyms	4-ethyl-2,3-dioxopiperazin-1-carbonylchlorid;	Article Data	8

4-Ethyl-2,3-dioxo-1-piperazine carbonyl chloride Synthetic route

: 32315-10-9
bis(trichloromethyl) carbonate

: 59702-31-7
1-ethyl-2,3-dioxo-piperazine

: 59703-00-3
4-ethyl-2,3-dioxopiperazine-1-carbonyl chloride

Conditions

Conditions	Yield
With pyridine; dmap; chloro-trimethyl-silane In dichloromethane at -25 - -20℃;	94.3%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 10 - 20℃; for 1.06667h; Temperature; Reagent/catalyst; Green chemistry;	93.9%
Stage #1: 1-ethyl-2,3-dioxo-piperazine With chloro-trimethyl-silane; triethylamine In dichloromethane at 0 - 20℃; for 1h; Inert atmosphere; Schlenk technique; Stage #2: bis(trichloromethyl) carbonate In dichloromethane at -30℃; Inert atmosphere; Schlenk technique;

: 75-44-5
phosgene

: 59702-31-7
1-ethyl-2,3-dioxo-piperazine

: 59703-00-3
4-ethyl-2,3-dioxopiperazine-1-carbonyl chloride

Conditions

Conditions	Yield
With chloro-trimethyl-silane; triethylamine In tetrahydrofuran; 1,4-dioxane

: 149-30-4
2-Mercaptobenzothiazole

A: 120600-74-0
S-2-benzothiazolyl-4-ethyl-2,3-dioxo-1-piperazinethio-carboxylate

B: 59703-00-3
4-ethyl-2,3-dioxopiperazine-1-carbonyl chloride

Conditions

Conditions	Yield
With triethylamine In dichloromethane

: 69-53-4
ampicillin

: 59703-00-3
4-ethyl-2,3-dioxopiperazine-1-carbonyl chloride

: 61477-96-1, 64131-97-1
piperacillin

Conditions

Conditions	Yield
With calcium carbonate In dichloromethane; water; ethyl acetate at 30 - 35℃; for 0.833333h;	93.7%
With sodium acetate; 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane; water; ethyl acetate at 5 - 10℃; for 0.916667h; pH=6.5 - 7.5; Temperature; Reagent/catalyst; Green chemistry;	92.8%
With triethylamine In water; ethyl acetate at 15 - 20℃; for 1h; pH=7.1;	123.5 g

: 72292-40-1, 72345-50-7, 72377-68-5
7β-<(2R)-2-phenyl-2-amino>acetylamino-1-carba-1-dethia-3-cephem-4-carboxylic acid

: 59703-00-3
4-ethyl-2,3-dioxopiperazine-1-carbonyl chloride

: 72292-42-3, 72401-86-6
7β-<(2R)-2-phenyl-2-(4-ethyl-2,3-dioxopiperazine-1-yl-carbonyl)amino>acetylamino-1-carba-1-dethia-3-cephem-4-carboxylic acid

Conditions

Conditions	Yield
	93%

: 3228-02-2
3-Methyl-4-isopropylphenol

: 59703-00-3
4-ethyl-2,3-dioxopiperazine-1-carbonyl chloride

: 4-isopropyl-3-methylphenyl N-(4-ethyl-2,3-dioxo-1-piperazine)carbamate

Conditions

Conditions	Yield
With triethylamine In acetonitrile at 20℃; for 4h;	92%

: 632-20-2
D-Threonine

: 59703-00-3
4-ethyl-2,3-dioxopiperazine-1-carbonyl chloride

: C11H17N3O6

Conditions

Conditions	Yield
With sodium carbonate In water at 20℃; for 11h; Reagent/catalyst; Solvent; Large scale;	90.2%

: 73910-33-5
7β-<(2R)-2-phenyl-2-amino>acetylamino-3-(1-methyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid

: 59703-00-3
4-ethyl-2,3-dioxopiperazine-1-carbonyl chloride

: 73910-34-6
7β-<(2R)-2-phenyl-2-(4-ethyl-2,3-dioxopiperazin-1-yl-carbonyl)amino>acetylamino-3-(1-methyl-1H-tetrazol-5-yl)thiomethyl-1-carba-1-dethia-3-cephem-4-carboxylic acid

Conditions

Conditions	Yield
With benzenesulfonamide; methyloxirane In acetonitrile for 0.416667h;	90%

: 1-Ethyl-4-trimethylsilanyl-piperazine-2,3-dione

: 59703-00-3
4-ethyl-2,3-dioxopiperazine-1-carbonyl chloride

: N,N'-carbonyl-bis-(4-ethyl-2,3-dioxopiperazine)

Conditions

Conditions	Yield
In dichloromethane at -5 - 25℃; for 8.67h; Solvent;	84%

: 22818-40-2
D-4-hydroxyphenylglycine

: 59703-00-3
4-ethyl-2,3-dioxopiperazine-1-carbonyl chloride

: 62893-24-7
(R)-<<(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl>amino>(4-hydroxyphenyl)acetic acid

Conditions

Conditions	Yield
With sodium carbonate; zinc dibromide In water at 200℃; for 3h; Temperature; Reagent/catalyst; Autoclave;	83.5%

4-Ethyl-2,3-dioxo-1-piperazine carbonyl chloride Chemical Properties

IUPAC Name: 4-ethyl-2,3-dioxopiperazine-1-carbonyl chloride
Molecular Formula:C₇H₉ClN₂O₃
Molecular Weight:204.610960 g/mol
Appearance:white crystal
Melting Point:100 °C
Water Solubility:decomposes
CAS DataBase Reference:59703-00-3(CAS DataBase Reference)
Synonyms of 4-ETHYL-2,3-DIOXO-1-PIPERAZINECARBONYLCHLORIDE(59703-00-3):
edpc;1-CHLOROCARBONYL-4-ETHYL-2,3-DIOXOPIPERAZINE;4-ETHYL-2,3-DIOXO-1-PIPERAZINECARBONYL CHLORIDE;4-ETHYL-2,3-DIOXO-PIPERAZINE-1-CARBONYL CHLORIDE;4-ETHYL-2,3-DIOXO-PIPERAZINE CARBONYL CHLORIDE;N-Ethyl-2,3-dioxypiperazine-1-carbonylchloride;N-Ethyl-2,3-dioxo-1-piperazinecarbonyl chloride;4-Ethyl-2,3-dioxo-1-piperazine carbonyl chlorides
Categories of 4-ETHYL-2,3-DIOXO-1-PIPERAZINECARBONYLCHLORIDE(59703-00-3):
Piperaizine;Piperazine derivates;Cefoperazone

4-Ethyl-2,3-dioxo-1-piperazine carbonyl chloride Uses

4-ETHYL-2,3-DIOXO-1-PIPERAZINECARBONYLCHLORIDE(59703-00-3) is an important pharmaceutical intermediate mainly used for synthesis of Piperacillin and cefoperazone, etc.

4-Ethyl-2,3-dioxo-1-piperazine carbonyl chloride Safety Profile

Safety Information of 4-ETHYL-2,3-DIOXO-1-PIPERAZINECARBONYLCHLORIDE(59703-00-3):
Hazard Codes:C
Risk Statements:34
34:Causes burns
Safety Statements:45-36/37/39-26
45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
36/37/39:Wear suitable protective clothing, gloves and eye/face protection
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice

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