- 4118-16-51,1'-((6-Phenyl-1,3,5-triazine-2,4-diyl)diimino)bisanthraquinone
- 41184-20-71,4-Benzenedisulfonicacid, 2-amino-, sodium salt (1:2)
- 41186-03-2Piperazine,1-(3-methylphenyl)-
- 41191-92-83-Amino-4-methylbenzoic acid ethyl ester
- 41192-80-78-Quinolinol,2-(trifluoromethyl)-
- 41192-84-14-Quinolinol,8-methoxy-2-(trifluoromethyl)-
- 41194-00-75-Hydroxy-1-methyl-2-pyrrolidone
- 41194-16-5Apramycin sulfate
- 41195-90-8Benzene,1,2-dichloro-3-isocyanato-
- 41197-29-9Methanesulfonylchloride, 1,1-dichloro-
Hot Products
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin
- 7631-86-9Silicon dioxide
- 302-79-4Tretinoin
- 77-92-9Citric acid
|
Basic Information |
|
Post buying leads |
|
Suppliers |
|
Cas Database |
| Name |
8-Hydroxyjulolidine |
EINECS | 255-247-9 |
| CAS No. | 41175-50-2 | Density | 1.23 g/cm3 |
| PSA | 23.47000 | LogP | 2.15600 |
| Solubility | Soluble in water (partly), ethanol, chloroform, methanol, and acetone. | Melting Point |
132-134 °C(lit.) |
| Formula | C12H15NO | Boiling Point | 374.427 °C at 760 mmHg |
| Molecular Weight | 189.257 | Flash Point | 213.494 °C |
| Transport Information | N/A | Appearance | pink to beige or brown fine crystalline powder |
| Safety | 22-24/25-37/39-26-36 | Risk Codes | 36/37/38 |
| Molecular Structure |
|
Hazard Symbols |
 Xi
|
| Synonyms |
2,3,6,7-Tetrahydro-1H,5H-pyrido[3,2,1-ij]quinolin-8-ol; |
Article Data | 31 |
8-Hydroxyjulolidine Synthetic route
| Conditions | Yield |
|---|---|
| With sodium carbonate In N,N-dimethyl-formamide at 75℃; for 9h; | 84.6% |
| With sodium carbonate In N,N-dimethyl-formamide at 80℃; for 15h; Inert atmosphere; | 69% |
| With sodium hydrogencarbonate In N,N-dimethyl-formamide at 70℃; | 68% |
| Conditions | Yield |
|---|---|
| Stage #1: m-Anisidine; 1.3-chlorobromopropane at 20 - 140℃; for 45.5h; Inert atmosphere; Reflux; Stage #2: With hydrogen iodide for 6h; Reflux; | 70.1% |
| Stage #1: m-Anisidine; 1.3-chlorobromopropane Heating; Stage #2: With hydrogen bromide for 3.5h; Heating; | 52% |
| at 95 - 180℃; | 39% |
| Stage #1: m-Anisidine; 1.3-chlorobromopropane With sodium carbonate at 100℃; for 11h; Stage #2: With hydrogenchloride; hydrogen iodide for 60h; Reflux; | |
| Stage #1: m-Anisidine; 1.3-chlorobromopropane With ammonium acetate at 140℃; for 15h; Inert atmosphere; Stage #2: With hydrogenchloride; hydrogen iodide In water for 24h; Reflux; Inert atmosphere; | 1.5 g |
- 63468-83-7
8-methoxy-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinoline
- 41175-50-2
8-hydroxyjulolidine
| Conditions | Yield |
|---|---|
| With hydrogenchloride; hydrogen iodide In water for 60h; Heating; | 67% |
| With hydrogenchloride; hydrogen iodide In water Reflux; | 67% |
| With hydrogen iodide In water Inert atmosphere; Reflux; | 1.32 g |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 64 percent / sodium carbonate, 4-A molecular sieves / a) from 70 deg C to 100 deg C, 3 h, b) reflux, 11 h 2: 67 percent / 47percent HI, conc. HCl / H2O / 60 h / Heating View Scheme |
- 536-90-3
m-Anisidine
- 41175-50-2
8-hydroxyjulolidine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: Heating 2: hydrogen iodide / Heating View Scheme | |
| Multi-step reaction with 2 steps 1: sodium carbonate / 14 h / 70 - 100 °C 2: hydrogenchloride; hydrogen iodide / water / Reflux View Scheme | |
| Multi-step reaction with 2 steps 1: sodium carbonate / 19 h / 70 - 150 °C 2: pyridine hydrochloride / 2 h / 200 °C View Scheme | |
| Multi-step reaction with 2 steps 1.1: sodium hydrogencarbonate / 2 h / 95 - 150 °C / Industrial scale 2.1: hydrogen iodide / 16 h / 110 °C / Industrial scale 2.2: pH 7 - 8 / Industrial scale View Scheme | |
| Multi-step reaction with 2 steps 1.1: sodium carbonate / 3 h / 65 - 100 °C / Industrial scale 2.1: hydrogen iodide / 16 h / 110 °C / Industrial scale 2.2: pH 7 - 8 / Industrial scale View Scheme |
- 41175-50-2
8-hydroxyjulolidine
- 1629670-53-6
C19H19NO7S2
| Conditions | Yield |
|---|---|
| In methanesulfonic acid at 150℃; for 0.25h; Sealed tube; | 100% |
- 41175-50-2
8-hydroxyjulolidine
- 1175621-48-3
5-(tert-butoxycarbonylamino)pent-2-ynoic acid
- 1386264-09-0
8-(2,3,6,7-tetrahydro-1H,5H-benzo[ij]quinolizine) 5-(tert-butoxycarbonylamino)pent-2-ynoate
| Conditions | Yield |
|---|---|
| With dmap; diisopropyl-carbodiimide In dichloromethane at 0℃; for 2h; Inert atmosphere; Sealed tube; | 98% |
- 41175-50-2
8-hydroxyjulolidine
- 99017-63-7
methyl 5-<(benzyloxycarbonyl)amino>-3-oxopentanoate
| Conditions | Yield |
|---|---|
| Stage #1: 8-hydroxyjulolidine; methyl 5-<(benzyloxycarbonyl)amino>-3-oxopentanoate With triisopropoxytitanium(IV) chloride In hexane Stage #2: With hydrogenchloride at 95℃; for 9h; | 98% |
| Stage #1: 8-hydroxyjulolidine; methyl 5-<(benzyloxycarbonyl)amino>-3-oxopentanoate With triisopropoxytitanium(IV) chloride In hexane; toluene for 12h; Reflux; Stage #2: With hydrogenchloride In water at 95℃; for 9h; | 4.3 g |
- 41175-50-2
8-hydroxyjulolidine
- 68-12-2, 33513-42-7
N,N-dimethyl-formamide
- 63149-33-7
9-formyl-8-hydroxyjulolidine
| Conditions | Yield |
|---|---|
| With trichlorophosphate at 0 - 80℃; for 1.25h; Inert atmosphere; | 97.6% |
| Stage #1: N,N-dimethyl-formamide With trichlorophosphate at 4℃; for 0.25h; Stage #2: 8-hydroxyjulolidine at 20 - 100℃; for 1h; | 94% |
| Stage #1: N,N-dimethyl-formamide With trichlorophosphate at 4℃; for 0.25h; Stage #2: 8-hydroxyjulolidine In water at 4 - 100℃; for 2.5h; | 94% |
- 41175-50-2
8-hydroxyjulolidine
- 182359-86-0
4-cyano-1-methyl-3-methylthio-1H-pyrrole-2,5-dione
| Conditions | Yield |
|---|---|
| In acetic acid Heating; | 96% |
8-Hydroxyjulolidine Chemical Properties
Following is the structure of 1H,5H-Benzo[ij]quinolizin-8-ol,2,3,6,7-tetrahydro- (CAS NO.41175-50-2):
Empirical Formula: C12H15NO
Molecular Weight: 189.2536 g/mol
EINECS: 255-247-9
Index of Refraction: 1.645
Molar Refractivity: 55.84 cm3
Molar Volume: 153.8 cm3
Density: 1.22 g/cm3
Flash Point: 213.5 °C
Melting point: 132-134 °C(lit.)
Surface Tension: 57 dyne/cm
Enthalpy of Vaporization: 64.62 kJ/mol
Boiling Point: 374.4 °C at 760 mmHg
Vapour Pressure: 3.88E-06 mmHg at 25 °C
Appearance: pink to beige or brown fine crystalline powder
Canonical SMILES: C1CC2=C3C(=C(C=C2)O)CCCN3C1
InChI: InChI=1S/C12H15NO/c14-11-6-5-9-3-1-7-13-8-2-4-10(11)12(9)13/h5-6,14H,1-4,7-8H2
InChIKey: FOFUWJNBAQJABO-UHFFFAOYSA-N
8-Hydroxyjulolidine Toxicity Data With Reference
H,5H-Benzo[ij]quinolizin-8-ol,2,3,6,7-tetrahydro- (CAS NO.41175-50-2) hasn't been listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
8-Hydroxyjulolidine Safety Profile
Hazard Codes: 
Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 22-24/25-37/39-26-36
S22:Do not breathe dust.
S24/25:Avoid contact with skin and eyes.
S37/39:Wear suitable gloves and eye/face protection.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
WGK Germany: 3
F: 10
8-Hydroxyjulolidine Specification
1H,5H-Benzo[ij]quinolizin-8-ol,2,3,6,7-tetrahydro- , its cas register number is 41175-50-2. It also can be called 2,3,6,7-Tetrahydro-1H,5H-benzo(ij)quinolizin-8-ol ; and 8-Hydroxyjulolidine .
1H,5H-Benzo[ij]quinolizin-8-ol,2,3,6,7-tetrahydro- (CAS NO.41175-50-2) could be stable under normal temperatures and pressures. It should avoid the condition like incompatible materials. It is not compatible with strong oxidizing agents. And also prevent it to broken down into hazardous decomposition products: irritating and toxic fumes and gases. However, its hazardous polymerization has not been reported.
What can I do for you?
Get Best Price
