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Cas Database |
| Name |
Aloxistatin |
EINECS | N/A |
| CAS No. | 88321-09-9 | Density | 1.102g/cm3 |
| PSA | 97.03000 | LogP | 1.79190 |
| Solubility | N/A | Melting Point |
126.2°C |
| Formula | C17H30 N2 O5 | Boiling Point | 538°C at 760 mmHg |
| Molecular Weight | 342.436 | Flash Point | 279.2°C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Moderately toxic by intraperitoneal route. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. | Risk Codes | 36/37/38 |
| Molecular Structure |
|
Hazard Symbols |
|
| Synonyms |
(2S,3S)-trans-epoxysuccinyl-L-leucylamido-3-methylbutane ethyl ester;aloxistatin;E64d inhibitor;EP 453;EP-453;epoxysuccinyl-leucylamide(3-methyl)butane ethyl ester;ethyl (+)-(2S,3S)-2,3-epoxy-N-((S)-1-(isopentylcarbamoyl)-3-methylbutyl)succinamate;ethyl 3-(3-methyl-1-(3-methylbutylcarbamoyl)butylcarbamoyl)-2-oxiranecarboxylate;ethyl epoxysuccinyl-leucylamido-3-methylbutane;loxistatin;loxistatin, (2S-(2alpha,3beta(R*)))-isomer;protease inhibitor E64d |
Article Data | 6 |
Aloxistatin Chemical Properties
IUPAC Name: Ethyl (2S,3S)-3-[[(2S)-4-methyl-1-(3-methylbutylamino)-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylate
The MF of EST (CAS NO.88321-09-9) is C17H30N2O5.
The MW of EST (CAS NO.88321-09-9) is 342.43.
Synonyms of EST (CAS NO.88321-09-9): (2s,3s)-trans-Epoxysuccinyl-l-leucylamido-3-methylbutane ethyl ester ; L-trans-Epoxysuccinyl-leu-3-methylbutylamide-ethyl ester
Index of Refraction: 1.485
Storage temp: -20 °C
Density: 1.102 g/ml
Flash Point: 279.2 °C
Boiling Point: 538 °C
Aloxistatin Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 3270mg/kg (3270mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 736, 1986. |
| mouse | LD50 | oral | > 10gm/kg (10000mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 736, 1986. | |
| mouse | LD50 | subcutaneous | > 7gm/kg (7000mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 736, 1986. | |
| rat | LD50 | intraperitoneal | 2050mg/kg (2050mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 736, 1986. |
| rat | LD50 | oral | > 10gm/kg (10000mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 736, 1986. |
| rat | LD50 | subcutaneous | > 5gm/kg (5000mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 736, 1986. |
Aloxistatin Safety Profile
Moderately toxic by intraperitoneal route. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.Safety information of EST (CAS NO.88321-09-9):
Hazard Codes 
Xi
Risk Statements
36/37/38 Irritating to eyes, respiratory system and skin
Safety Statements
26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36 Wear suitable protective clothing
WGK Germany 2
RTECS RR0404300
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