Name: Aloxistatin
SKU: 88321-09-9

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Basic Information

Molecular Structure:
CAS No.:	88321-09-9
Name:	Aloxistatin
Article Data:	6

Formula:	C17H30 N2 O5
Molecular Weight:	342.436
Synonyms:	(2S,3S)-trans-epoxysuccinyl-L-leucylamido-3-methylbutane ethyl ester;aloxistatin;E64d inhibitor;EP 453;EP-453;epoxysuccinyl-leucylamide(3-methyl)butane ethyl ester;ethyl (+)-(2S,3S)-2,3-epoxy-N-((S)-1-(isopentylcarbamoyl)-3-methylbutyl)succinamate;ethyl 3-(3-methyl-1-(3-methylbutylcarbamoyl)butylcarbamoyl)-2-oxiranecarboxylate;ethyl epoxysuccinyl-leucylamido-3-methylbutane;loxistatin;loxistatin, (2S-(2alpha,3beta(R*)))-isomer;protease inhibitor E64d
Density:	1.102g/cm³
Melting Point:	126.2°C
Boiling Point:	538°C at 760 mmHg
Flash Point:	279.2°C
Hazard Symbols:
Risk Codes:	36/37/38
Safety:	Moderately toxic by intraperitoneal route. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x.
PSA:	97.03000
LogP:	1.79190

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Chemistry

IUPAC Name: Ethyl (2S,3S)-3-[[(2S)-4-methyl-1-(3-methylbutylamino)-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylate
The MF of EST (CAS NO.88321-09-9) is C₁₇H₃₀N₂O₅.

The MW of EST (CAS NO.88321-09-9) is 342.43.
Synonyms of EST (CAS NO.88321-09-9): (2s,3s)-trans-Epoxysuccinyl-l-leucylamido-3-methylbutane ethyl ester ; L-trans-Epoxysuccinyl-leu-3-methylbutylamide-ethyl ester
Index of Refraction: 1.485
Storage temp: -20 °C
Density: 1.102 g/ml
Flash Point: 279.2 °C
Boiling Point: 538 °C

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	3270mg/kg (3270mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 736, 1986.
mouse	LD50	oral	> 10gm/kg (10000mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 736, 1986.
mouse	LD50	subcutaneous	> 7gm/kg (7000mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 736, 1986.
rat	LD50	intraperitoneal	2050mg/kg (2050mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 736, 1986.
rat	LD50	oral	> 10gm/kg (10000mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 736, 1986.
rat	LD50	subcutaneous	> 5gm/kg (5000mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 736, 1986.

Safety Profile

Moderately toxic by intraperitoneal route. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x.Safety information of EST (CAS NO.88321-09-9):
Hazard Codes Irritant Xi
Risk Statements
36/37/38 Irritating to eyes, respiratory system and skin
Safety Statements
26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36 Wear suitable protective clothing
WGK Germany 2
RTECS RR0404300