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Cas Database

Name	Amsacrine hydrochloride	EINECS	257-094-3
CAS No.	54301-15-4	Density	N/A
PSA	88.70000	LogP	6.54050
Solubility	N/A	Melting Point	197-199 ºC
Formula	C21H19 N3 O3 S . Cl H	Boiling Point	563°C at 760 mmHg
Molecular Weight	429.927	Flash Point	294.3°C
Transport Information	UN 2811	Appearance	N/A
Safety	Poison by ingestion, subcutaneous and intraperitoneal routes. Mutation data reported. See also SULFONATES. When heated to decomposition it emits very toxic fumes of NO_x, SO_x, and HCl.	Risk Codes	R25;R36/37/38
Molecular Structure		Hazard Symbols
Synonyms	Methanesulfonamide,N-[4-(9-acridinylamino)-3-methoxyphenyl]-, monohydrochloride (9CI);4'-(Acridin-9-ylamino)-3'-methoxymethanesulfonanilide hydrochloride; AMSAhydrochloride; Amsacrine hydrochloride;N-[4-(9-Acridinylamino)-3-methoxyphenyl]methanesulfonamide hydrochloride; NSC141549; m-AMSA hydrochloride	Article Data	2

Amsacrine hydrochloride Chemical Properties

4-(9-Acridinylamino)-N-(methanesulfonyl)-m-anisidine hydrochloride (54301-15-4) has the Molecular Formula of C₂₁H₁₉N₃O₃S^.ClH,the Molecular Weight of 429.95.And 4-(9-Acridinylamino)-N-(methanesulfonyl)-m-anisidine hydrochloride (54301-15-4)'s Melting Point is between 197^oC and 199 ^oC. It would be crystal when it is in Mp of 231–232^oC. Besides,4-(9-ACRIDINYLAMINO)METHANESULFON-m-ANISIDE MONOHYDROCHLORIDE (54301-15-4) can also be called 4-(9-Acridinylamino)methanesulfon-m-aniside monohydrochloride ;m-Amsa hydrochloride ; Methanesulfonamide, N-(4-(9-acridinylamino)-3-methoxyphenyl)-, monohydrochloride ; Methanesulfon-m-anisidine, 4-((9-acridinyl)amino)-, hydrochloride ;Methanesulfonyl-m-anisidine, 4'-(9-acridinylamino)-, monohydrochloride ;NCI-C03190 or NSC 141549 .
The structure:

Amsacrine hydrochloride Uses

4-(9-ACRIDINYLAMINO)METHANESULFON-m-ANISIDE MONOHYDROCHLORIDE (54301-15-4) can be used for antineoplastic.

Amsacrine hydrochloride Toxicity Data With Reference

1.	dnd-mus:leu 2500 μg/L	CNREA8 Cancer Research. 38 (1978),1329.
2.	dns-mus-ipr 5 mg/kg	CNREA8 Cancer Research. 38 (1978),1329.
3.	oms-ham:ovr 2 mg/L	JNCIAM Journal of the National Cancer Institute. 60 (1978),1147.
4.	cyt-ham:ovr 2 mg/L	JNCIAM Journal of the National Cancer Institute. 60 (1978),1147.
5.	sce-ham:ovr 50 μg/L	JNCIAM Journal of the National Cancer Institute. 60 (1978),1155.
6.	orl-mus LD50:181 mg/kg	NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program, Bethesda, MD 20205 JAN86 .
7.	ipr-mus LD50:20,560 μg/kg	NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program, Bethesda, MD 20205 JAN86 .
8.	scu-mus LD50:110 mg/kg	NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program, Bethesda, MD 20205 JAN86 .

Amsacrine hydrochloride Safety Profile

Poison by ingestion, subcutaneous and intraperitoneal routes. Mutation data reported. See also SULFONATES. When heated to decomposition 4-(9-ACRIDINYLAMINO)METHANESULFON-m-ANISIDE MONOHYDROCHLORIDE (54301-15-4) emits very toxic fumes of NO_x, SO_x, and HCl.
The sign of dangerous goods is T.The dangerous types of code are R25 and R36/37/38.
Lastly,the transport of Dangerous Goods Code is UN 2811.

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