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Cas Database |
| Name |
Bromoperidol |
EINECS | 233-943-3 |
| CAS No. | 10457-90-6 | Density | 1.367 g/cm3 |
| PSA | 40.54000 | LogP | 4.47260 |
| Solubility | insoluble in water | Melting Point |
156-158 °C |
| Formula | C21H23BrFNO2 | Boiling Point | 543.598 °C at 760 mmHg |
| Molecular Weight | 420.322 | Flash Point | 282.558 °C |
| Transport Information | N/A | Appearance | Tan solid |
| Safety | Risk Codes | 22 | |
| Molecular Structure |
|
Hazard Symbols | Xn |
| Synonyms |
Butyrophenone,4-[4-(p-bromophenyl)-4-hydroxypiperidino]-4'-fluoro- (8CI);4-[4-(4-Bromophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone;Azurene;4-[4-(4-Bromophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one; |
Article Data | 4 |
Bromoperidol Chemical Properties
Chemistry informtion about Bromoperidol (CAS NO.10457-90-6) is:
IUPAC Name: 4-[4-(4-Bromophenyl)-4-Hydroxypiperidin-1-Yl]-1-(4-Fluorophenyl)Butan-1-One
Product Categories: Aromatics ; Heterocycles ; Intermediates & Fine Chemicals ; Pharmaceuticals
Empirical Formula: C21H23BrFNO2
Molecular Weight: 420.3152
EINECS: 233-943-3
Density: 1.366 g/cm3
Melting Point: 156-158°C
Flash Point: 282.6 °C
Boiling Point: 543.6 °C at 760 mmHg
Vapour Pressure: 1.19E-12 mmHg at 25°C
Enthalpy of Vaporization: 86.51 kJ/mol
H bond acceptors: 3
H bond donors: 1
Freely Rotating Bonds: 7
Polar Surface Area: 29.54 Å2
Index of Refraction: 1.59
Molar Refractivity: 103.8 cm3
Molar Volume: 307.5 cm3
Surface Tension: 48.5 dyne/cm
SMILES: Fc1ccc(cc1)C(=O)CCCN3CCC(O)(c2ccc(Br)cc2)CC3
InChI: InChI=1/C21H23BrFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
Following is the molecular structure of Bromoperidol (CAS NO.10457-90-6):
Bromoperidol History
It was discovered at Janssen Pharmaceutica in 1966.
Bromoperidol Uses
Bromoperidol (CAS NO.10457-90-6) is used as Bromine analog of Haloperidol. Antipsychotic.Also it used as an antipsychotic in the treatment of schizophrenia.
Bromoperidol Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 156mg/kg (156mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 16, Pg. 1461, 1985. | |
| mouse | LD50 | intravenous | 18900ug/kg (18.9mg/kg) | sense organs and special senses: ptosis: eye behavioral: tremor behavioral: somnolence (general depressed activity) | Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 45, 1974. |
| mouse | LD50 | oral | 174mg/kg (174mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 16, Pg. 1461, 1985. | |
| mouse | LD50 | subcutaneous | 114mg/kg (114mg/kg) | sense organs and special senses: ptosis: eye behavioral: somnolence (general depressed activity) behavioral: tremor | Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 45, 1974. |
| rat | LD50 | intraperitoneal | 323mg/kg (323mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 16, Pg. 1461, 1985. | |
| rat | LD50 | intravenous | 10mg/kg (10mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 16, Pg. 1461, 1985. | |
| rat | LD50 | oral | 359mg/kg (359mg/kg) | sense organs and special senses: ptosis: eye behavioral: somnolence (general depressed activity) behavioral: tremor | Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 45, 1974. |
| rat | LD50 | subcutaneous | 84mg/kg (84mg/kg) | sense organs and special senses: ptosis: eye behavioral: somnolence (general depressed activity) behavioral: tremor | Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 45, 1974. |
Bromoperidol Safety Profile
Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of F−, Br− and NOx.
Bromoperidol Specification
Bromoperidol , with CAS number of 10457-90-6, can be called 4-(4-(4-Bromophenyl)-4-Hydroxy-1-Piperidinyl)-1-(4-Fluorophenyl)-1-Butanon ; 4-(4-(4-Bromophenyl)-4-Hydroxypiperidino)-4’-Fluorobutyrophenone ; 4-(4-(P-Bromophenyl)-4-Hydroxypiperidino)-4’-Fluoro-Butyrophenon ; 4-(4-(P-Bromophenyl)-4-Hydroxypiperidino)-4’-Fluorobutyrophenone ; 4-(4-(P-Bromophenyl)-4-Hydroxypiperidinol)-4’-Fluorobutyrophenone ; Bromoperidol ; 4-[4-(4-Bromophenyl)-4-Hydroxy-1-Piperidinyl]-1-(4-Fluorophenyl)-1-Butanone . Bromoperidol (CAS NO.10457-90-6) is a tan solid. And it is a drug which is a butyrophenone derivative. It is a potent and long-acting neuroleptic.
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