10457-90-6

Basic information

• Product Name: BROMPERIDOL
• Synonyms: R 11333;4-(4-(4-bromophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanon;4-(4-(4-bromophenyl)-4-hydroxypiperidino)-4’-fluorobutyrophenone;4-(4-(p-bromophenyl)-4-hydroxypiperidino)-4’-fluoro-butyrophenon;4-(4-(p-bromophenyl)-4-hydroxypiperidino)-4’-fluorobutyrophenone;4-(4-(p-bromophenyl)-4-hydroxypiperidinol)-4’-fluorobutyrophenone;bromoperidol;4-[4-(4-BROMOPHENYL)-4-HYDROXY-1-PIPERIDINYL]-1-(4-FLUOROPHENYL)-1-BUTANONE
• CAS NO: 10457-90-6
• Molecular Formula: C₂₁H₂₃BrFNO₂
• Molecular Weight: 420.32
• EINECS: 233-943-3
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;XEFO
• Mol File: 10457-90-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 156-158°C
• Boiling Point: 215.2°C (rough estimate)
• Flash Point: 282.558 °C
• Appearance: white/solid
• Density: 1.3109 (estimate)
• Vapor Pressure: 1.19E-12mmHg at 25°C
• Refractive Index: 1.59
• Storage Temp.: Refrigerator
• Solubility: H2O: insoluble
• PKA: 8.6-8.7(at 25℃)
• CAS DataBase Reference: BROMPERIDOL(CAS DataBase Reference)
• NIST Chemistry Reference: BROMPERIDOL(10457-90-6)
• EPA Substance Registry System: BROMPERIDOL(10457-90-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• RTECS: EU1180000
• Hazardous Substances Data: 10457-90-6(Hazardous Substances Data)

Usage

Description

BROMPERIDOL is a bromine analog of Haloperidol, a compound with antipsychotic properties. It is a tan solid, which is known for its use in various medical applications due to its pharmacological effects.

Uses

Used in Pharmaceutical Industry:
BROMPERIDOL is used as an antipsychotic agent for the treatment of various psychiatric disorders. It helps in managing symptoms such as hallucinations, delusions, and agitation associated with conditions like schizophrenia and bipolar disorder.
Used in Pain Management:
BROMPERIDOL is used as an analgesic to alleviate pain. Its effectiveness in pain relief can be beneficial for patients suffering from acute or chronic pain conditions.
Used in Inflammation Reduction:
BROMPERIDOL is also used as an anti-inflammatory agent, which can help in reducing inflammation and associated discomfort in various medical conditions.

InChI:InChI=1/C21H23BrFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2

Upstream product

• 114361-10-3 4-<4-hydroxy-4-(4-aminophenyl)piperidinyl>-1-(4-fluorophenyl)butanone 
• 3874-54-2 4-(4-fluorophenyl)-4-oxo-n-butyl chloride 
• 57988-58-6 4-(4-bromophenyl)-4-hydroxy-piperidine 
• 97042-48-3 4-<4-<4-(trimethylstannyl)phenyl>-4-hydroxypiperidino>-4'-fluorobutyrophenone 

Downstream Products

• 366-77-8 4-(4-fluorophenyl)-4-oxopropionic acid 

Related news

Comparison of prolactin concentrations between haloperidol and BROMPERIDOL (cas 10457-90-6) treatments in schizophrenic patients08/03/2019

The antipsychotic drug, bromperidol, is a close structural analogue of haloperidol. These two drugs also have similarities in metabolic pathways and pharmacological properties. In the present study, the prolactin concentrations in plasma during bromperidol versus haloperidol treatments were comp...detailed

Repurposing antipsychotic drugs into antifungal agents: Synergistic combinations of azoles and BROMPERIDOL (cas 10457-90-6) derivatives in the treatment of various fungal infections07/31/2019

As the number of hospitalized and immunocompromised patients continues to rise, invasive fungal infections, such as invasive candidiasis and aspergillosis, threaten the life of millions of patients every year. The azole antifungals are currently the most prescribed drugs clinically that display ...detailed

Relevant articles and documents

Repurposing antipsychotic drugs into antifungal agents: Synergistic combinations of azoles and bromperidol derivatives in the treatment of various fungal infections

As the number of hospitalized and immunocompromised patients continues to rise, invasive fungal infections, such as invasive candidiasis and aspergillosis, threaten the life of millions of patients every year. The azole antifungals are currently the most prescribed drugs clinically that display broad-spectrum antifungal activity and excellent oral bioavailability. Yet, the azole antifungals have their own limitations and are unable to meet the challenges associated with increasing fungal infections and the accompanied development of resistance against azoles. Exploring combination therapy that involves the current azoles and another drug has been shown to be a promising strategy. Haloperidol and its derivative, bromperidol, were originally discovered as antipsychotics. Herein, we synthesize and report a series of bromperidol derivatives and their synergistic antifungal interactions in combination with a variety of current azole antifungals against a wide panel of fungal pathogens. We further select two representative combinations and confirm the antifungal synergy by performing time-kill assays. Furthermore, we evaluate the ability of selected combinations to destroy fungal biofilm. Finally, we perform mammalian cytotoxicity assays with the representative combinations against three mammalian cell lines.

Antifungal Compositions

Provided herein are antifungal compositions and methods of use thereof. The antifungal compositions include an antifungal agent and an antipsychotic agent or an antihistamine. The methods of use thereof include administering a composition including an antifungal agent and an antipsychotic or an antihistamine to a plant or animal in need thereof.