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Name	Buclizine	EINECS	N/A
CAS No.	82-95-1	Density	0.9970 (rough estimate)
PSA	6.48000	LogP	6.42050
Solubility	N/A	Melting Point	N/A
Formula	C28H33 Cl N2	Boiling Point	bp0.001 217-220°
Molecular Weight	433.036	Flash Point	N/A
Transport Information	N/A	Appearance	N/A
Safety	Experimental reproductive effects. When heated to decomposition it emits toxic vapors of NO_x and Cl⁻.	Risk Codes	N/A
Molecular Structure		Hazard Symbols	N/A
Synonyms	Piperazine,1-(p-tert-butylbenzyl)-4-(p-chloro-a-phenylbenzyl)- (6CI,7CI,8CI); 1-(p-Chloro-a-phenylbenzyl)-4-(p-tert-butylbenzyl)piperazine;1-(p-Chlorobenzhydryl)-4-(p-tert-butylbenzyl)-diethylenediamine;1-(p-Chlorobenzhydryl)-4-(p-tert-butylbenzyl)-piperazine;1-(p-tert-Butylbenzyl)-4-(p-chloro-a-phenylbenzyl)piperazine; AH 2526; Aphilan R base; Buclifen; Buclizine;Histabuticine; Histabutizine; Histabutyzine; Hitabutyzyne; Posdel; Postafen	Article Data	7

Buclizine Chemical Properties

Chemistry informtion about Buclizine (CAS NO.82-95-1) is:
IUPAC Name: 1-[(4-Tert-Butylphenyl)Methyl]-4-[(4-Chlorophenyl)-Phenylmethyl]Piperazine
Synonyms: 1-(4-Tert-Butylbenzyl)-4-[(4-Chlorophenyl)(Phenyl)Methyl]Piperazine ; 1-(P-Tert-Butylbenzyl)-4-(P-Chloro-Alpha-Phenylbenzyl)-Piperazin ; 1-(P-Tert-Butylbenzyl)-4-(P-Chloro-Alpha-Phenylbenzyl)Piperazine ; 1-[4-(Chlorophenyl)Phenylmethyl]-4-[[4-(1,1-Dimethylethyl)Phenyl]Methyl]Piperrazine ; Ah 2526 ; Ah2526 ; Aphilan-R Base ; Aphilan-Rbase
MF: C₂₈H₃₃ClN₂
MW: 433.03
EINECS: 201-448-1
Density: 1.117 g/cm³
Flash Point: 268.3 °C
Boiling Point: 520.1 °C at 760 mmHg
Vapour Pressure: 6.44E-11 mmHg at 25°C
Enthalpy of Vaporization: 79.3 kJ/mol
Following is the molecular structure of Buclizine (CAS NO.82-95-1) is:

Buclizine Uses

Buclizine (CAS NO.82-95-1) is a piperazine-derivative antihistamine used as an antivertigo/antiemetic agent. Buclizine is used in the prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness. Additionally, it has been used in the management of vertigo in diseases affecting the vestibular apparatus. Although the mechanism by which buclizine exerts its antiemetic and antivertigo effects has not been fully elucidated, its central anticholinergic properties are partially responsible. The drug depresses labyrinth excitability and vestibular stimulation, and it may affect the medullary chemoreceptor trigger zone. It also possesses anticholinergic, antihistaminic, central nervous system depressant, and local anesthetic effects. For prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness and vertigo (dizziness caused by other medical problems).

Buclizine Production

Raw materials are Paraformaldehyde --> Aluminium Chloride Hexahydrate --> Tert-Butylbenzene --> 1-Benzylpiperazine --> Bromo(4-Chlorophenyl)Phenyl Methane .

Buclizine Safety Profile

Experimental reproductive effects. When heated to decomposition it emits toxic vapors of NO_x and Cl⁻.

Buclizine Specification

Buclizine (CAS NO.82-95-1) is an antihistamine of the piperazine derivative family. It is considered to be an antiemetic, similar to meclizine. Buclizine is categorized under the following by the FDA: Antiemetics ; Antihistamine ; Anticholinergic ; ATC:R06AE01

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