- Preparation method for Selexipag intermediate
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The invention provides a method for preparing a Selexipag intermediate 4-((5,6-diphenyl-2-pyrazinyl)(1-methylethyl)amino)-1-butanol. The method includes protecting 4-isopropylamino n-butyl alcohol byusing a hydroxy protecting group reagent, performs addition with 5,6-diphenyl-2-pyrazinyl trifluoromethanesulfonate, and obtains a target compound by removing protecting groups. The preparation methodis high in yield, low in production cost, mild in condition, simple in operation and suitable for industrial production.
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Paragraph 0061-0064
(2019/03/15)
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- Preparation method for therapeutic drug selexipag for treating pulmonary arterial hypertension of adults
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The invention discloses a preparation method for therapeutic drug selexipag for treating pulmonary arterial hypertension of adults. The therapeutic drug selexipag for treating pulmonary arterial hypertension of adults is prepared through 5-step reaction of starting materials 5-chlorine-2 and 3-diphenyl pyrazine. The invention aims to overcome the defect of higher cost of the present method, shorten the preparation process and provide the preparation method for the therapeutic drug selexipag for treating pulmonary arterial hypertension of adults that is mild in reaction, easy in operation and high in chiral purity.
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Paragraph 0017; 0018
(2017/08/31)
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- Studies on pyrazines. 35 [1]. An improved synthesis of bromopyrazines from hydroxypyrazines
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The synthesis of bromopyrazines from hydroxypyrazines was successfully effected by the procedure via trimethylsilyloxypyrazines, the sequence of which proceeds under mild conditions and does not require the isolation of intermediate.
- Sato, Nobuhiro,Narita, Nobuhiko
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p. 783 - 786
(2007/10/03)
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