101727-15-5

Basic information

• Product Name: 2-iodo-5,6,-diphenylpyrazine
• Synonyms: 2-iodo-5,6,-diphenylpyrazine
• CAS NO: 101727-15-5
• Molecular Weight: 358.181
• Mol File: 101727-15-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 399.9±42.0 °C(Predicted)
• Density: 1.567±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-iodo-5,6,-diphenylpyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-iodo-5,6,-diphenylpyrazine(101727-15-5)
• EPA Substance Registry System: 2-iodo-5,6,-diphenylpyrazine(101727-15-5)

Safety Data

• Hazardous Substances Data: 101727-15-5(Hazardous Substances Data)

Upstream product

• 41270-66-0 2-chloro-5,6-diphenylpyrazine 
• 18591-57-6 5,6-diphenyl-2-hydroxypyrazine 
• 243472-82-4 2,3-diphenyl-5-trimethylsilanyloxy-pyrazine 

Downstream Products

• 475084-96-9 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}acetic acid tert-butyl ester 
• 475085-57-5 MRE-269 
• 475086-01-2 Selexipag 
• 475086-75-0 4-[N-(5,6-diphenylpyrazine-2-yl)-N-isopropylamino]-1-butanol 

Relevant articles and documents

Preparation method for Selexipag intermediate

The invention provides a method for preparing a Selexipag intermediate 4-((5,6-diphenyl-2-pyrazinyl)(1-methylethyl)amino)-1-butanol. The method includes protecting 4-isopropylamino n-butyl alcohol byusing a hydroxy protecting group reagent, performs addition with 5,6-diphenyl-2-pyrazinyl trifluoromethanesulfonate, and obtains a target compound by removing protecting groups. The preparation methodis high in yield, low in production cost, mild in condition, simple in operation and suitable for industrial production.

Studies on pyrazines. 35 [1]. An improved synthesis of bromopyrazines from hydroxypyrazines

The synthesis of bromopyrazines from hydroxypyrazines was successfully effected by the procedure via trimethylsilyloxypyrazines, the sequence of which proceeds under mild conditions and does not require the isolation of intermediate.