- A novel and one step procedure for preparation of α-bromo-α,β-unsaturated carbonyl compounds
-
A new one step method is developed for the preparation of α-bromo-α,β-unsaturated carbonyl compounds in moderate to good yields from corresponding α,β-unsaturated carbonyl compounds using DMP [1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3(IH)-one] and te
- Ramanarayanan,Shukla, Vidyanand G.,Akamanchi
-
-
Read Online
- A selective transformation of flavanones to 3-bromoflavones and flavones under microwave irradiation
-
This paper presents the first report of a highly selective transformation of flavanones to 3-bromoflavones or flavones by microwave irradiation of the corresponding flavanone reactants and N-bromosuccinimide (NBS) in the presence of a catalytic amount of 2,2′-azobis(isobutyronitrile) (AIBN). The combination of good to excellent yields, shorter reaction time (10 min), and high levels of functional group compatibility make this an attractive synthetic approach to 3-bromoflavones and flavones.
- Zhou, Zhongzhen,Zhao, Peiliang,Huang, Wei,Yang, Guangfu
-
-
Read Online
- Synthesis of 1,3-thioxoketones from salicylaldehyde
-
A method for the synthesis of monothiodibenzoylmethanes was developed. The method involves a reaction of potassium thioacetate with 1-(2-hydroxyphenyl)-3- phenylpropynone prepared from salicylaldehyde.
- Semenova,Yarovenko,Levchenko,Krayushkin
-
p. 1022 - 1025
(2014/03/21)
-
- An efficient synthesis of 3-bromoflavones under solvent free conditions using grinding technique
-
Selective bromination of 1-(2-hydroxyphenyl)-3-phenylpropane- 1,3-diones has been carried out with ammonium bromide and ammonium persulphate at room temperature using grinding technique under solvent free conditions to give 2-bromo derivatives which on cyclodehydration with p-toluenesulphonic acid under grinding conditions give 3-bromoflavones. Also, flavones on bromination using above mentioned conditions give 3-bromoflavones directly.
- Jakhar, Komal,Makrandi
-
p. 770 - 773
(2012/06/30)
-
- A new synthesis of 5-arylbenzo[c]xanthones from photoinduced electrocyclisation and oxidation of (E)-3-styrylflavones
-
A new synthetic route to 5-arylbenzo[c]xanthones is -established. This was accomplished by use the Heck reaction of 3-bromoflavones with styrene derivatives, leading to (E)-3-styrylflavones with total diastereoselectivity. This transformation was greatly improved under microwave irradiation. The one-pot, photoinduced electrocyclisation of (E)-3-styrylflavones and further in situ oxidation of the cycloadduct leads to 5-arylbenzo[c]xan-thones. Georg Thieme Verlag Stuttgart · New York.
- Rocha, Djenisa H. A.,Pinto, Diana C. G. A.,Silva, Artur M. S.,Patonay, Tamás,Cavaleiro, José A. S.
-
experimental part
p. 559 - 564
(2012/04/04)
-
- A new synthesis of novel alkenylated flavones by palladium-catalyzed cross-coupling reactions
-
Bromoflavones were treated with various terminal alkynes in palladium-catalyzed cross-coupling reactions under phosphine-free condions to give the expected alkenylated flavones in moderate to good yields. The presence of two different β hydrogens in the t
- Fekete, Szabolcs,Patonay, Tamas,Silva, Artur M. S.,Cavaleiro, Jose A. S.
-
p. 210 - 225
(2013/09/24)
-
- Facile synthesis of new substituted 3-aryl/heteroarylflavones by Suzuki-Miyaura coupling of 3-bromoflavone with substituted aryu heteroarylboronic acids
-
Flavones 7a-k having aryl and heteroaryl substituents at 3-position were synthesized in a Panasonic microwave-oven by Suzuki-Miyaura cross coupling reaction using 3-bromoflavone 5 and substituted aryl and heteroaryl boronic acids 6a-k with tetrakistriphenylphospine-palladium |(C6H 6)3P]4Pd as catalyst and N,N-dimethylformamide (DMF)+ H2O (9:4) as solvent, and aq.Na2CO3(2N) as base.
- Joshi, Vidya,Hatim, Jaywant Govind
-
p. 111 - 116
(2013/09/24)
-
- PHARMACEUTICAL COMPOUNDS
-
The invention relates to a series of compounds with particular activity as inhibitors of the serine-threonine kinase AKT. Also provided are pharmaceutical compositions comprising same as well as methods for treating cancer.
- -
-
Page/Page column 89
(2011/04/19)
-
- New synthesis of 3-bromoflavones via bromination of 1-(2-hydroxyphenyl)-3- arylpropane-1,3-dione by CuBr2, and conversion into 3-aminoflavones
-
A new synthesis of 3-bromoflavones from 1-(2-hydroxyphenyl)-3-arylpropane- 1,3-dione using CuBr2 is described. The usefulness of 3-bromoflavone as a precursor of 3-aminoflavone is also described. Copyright
- Miyake, Hideyoshi,Nishino, Shouko,Nishimura, Akinori,Sasaki, Mitsura
-
p. 522 - 523
(2008/02/10)
-
- Microwave enhanced palladium catalysed coupling reactions: A diversity-oriented synthesis approach to functionalised flavones
-
Microwave enhanced diversity-oriented synthesis (MEDOS) using palladium catalysed protocols is introduced as a powerful new strategy for the synthesis of systematically modified small molecules and is highlighted by application to functionalised flavones. The Royal Society of Chemistry 2006.
- Fitzmaurice, Richard J.,Etheridge, Zac C.,Jumel, Emelie,Woolfson, Derek N.,Caddick, Stephen
-
p. 4814 - 4816
(2007/10/03)
-
- Synthesis of 3-halogenated flavonoids via electrophile-promoted cyclization of 2-(3-aryl-2-propynoyl)anisoles
-
Treatment of 2-(1-aryl-3-propynoyl) anisoles 1 with N-chlorosuccinimide (NCS) or N-bromosuccinimide (NBS) gave the 3-halogenated flavones and their related molecules in moderate yields.
- Lin, Chi-Fong,Duh, Tsai-Hui,Lu, Wen-Der,Lee, Jeng-Lin,Lee, Chia-Ying,Chen, Chin-Chau,Wu, Ming-Jung
-
p. 183 - 186
(2007/10/03)
-
- Selective halogenation of 1-(2-hydroxyphenyl)-3-phenylpropane-1,3-diones using phase transfer catalysis and synthesis of 3-chloro- and 3-bromo-flavones
-
Selective chlorination and bromination of 1-(2-hydroxyphenyl)-3-phenylpropane-1,3-diones have been achieved by their reaction with ammonium chloride/ammonium bromide and hydrogen peroxide in biphase medium using phase transfer catalysis.
- Makrandi,Shashi,Kumar, Surender
-
p. 895 - 896
(2007/10/03)
-
- Synthesis of 3-bromo derivatives of flavones
-
Various 3-halo flavones were prepared by reaction of the corresponding flavone derivatives with R4NBr/PhI(OAc)2 system under mild reaction conditions.
- Rho, Ho Sik,Ko, Byoung-Seob,Kim, Ho Kyoung,Ju, Young-Sung
-
p. 1303 - 1310
(2007/10/03)
-
- A convenient synthesis of 3-bromoflavones
-
The reaction of flavones with 2,4,4,6-tetrabromo-2,5-cyclo hexadienone(1) gave the corresponding 3-bromoflavones under the mild reaction condition. Flavones containing easily oxidizable functional groups were also brominated without deleterious oxidation
- Joo, Yung Hyup,Kim, Jin Kwan,Kang, Seon-Hwa
-
p. 1653 - 1658
(2007/10/03)
-
- A facile synthetic method of 3-bromoflavones
-
The synthesis of 3-bromoflavones by bromination-debromination using pyridinium bromide perbromide is described.
- Joo, Yung Hyup,Kim, Jin Kwan
-
p. 4287 - 4293
(2007/10/03)
-
- Synthesis of halogenated/nitrated flavone derivatives and evaluation of their affinity for the central benzodiazepine receptor
-
A series of halogenated/nitrated flavone compounds were synthesized. Some of the products were found to be potent central benzodiazepine receptor (BDZ-R) ligands. The structure-activity relationships (SAR) analysis of the new synthetic compounds, together with that of others already described, indicates that substitutions at position 6 or 6 and 3' in the flavone nucleus are the only ones that give rise to high affinity BDZ-R ligands.
- Marder, Mariel,Zinczuk, Juan,Colombo, Maria I.,Wasowski, Cristina,Viola, Haydee,Wolfman, Claudia,Medina, Jorge H.,Ruveda, Edmundo A.,Paladini, Alejandro C.
-
p. 2003 - 2008
(2007/10/03)
-
- Synthesis of 3-N-Substituted Aminoflavones as Potential CNS Agents
-
3-N-Substituted aminoflavones (VI) have been synthesized by the action of appropriate secondary amines on 3-bromoflavone (III).In the preparation of III by a known procedure involving the bromination of flavone (II), a mixture of three products has been obtained rather than one product as reported by Pendse .The structures of VI and two of the bromination products have been established on the basis of their elemental analyses and spectral data.Compounds VI exhibit weak CNS depressant, hypotensive and hyperthermic activities.
- Kapoor, R. P.,Rastogi, M. K.,Garg, C. P.
-
p. 285 - 286
(2007/10/02)
-
- Reactions of Flav-2-enes and Flav-2-en-4-ones (Flavones)
-
Flav-2-enes, flavones, and 3-alkyl ethers of flavonols add alcohols and carboxylic acids in the presence of N-bromosuccinimide to give 2-alkoxy- and 2-acyloxy-3-bromoflavans which provide routes to cis-3-bromoflavans by reduction and to 3,4-diols by elimination and reaction with osmium tetraoxide.The 2-acyloxyflavans react with alcohols yielding 2-alkoxyflavans.Flavonols react with N-bromosuccinimide and alcohols to give bromine-free hemiacetals, the known 2,3-dialkoxy-3-hydroxyflavanones.
- Bird, T. Geoffrey C.,Brown, Ben R.,Stuart, Ian A.,Tyrrell, William R.
-
p. 1831 - 1846
(2007/10/02)
-