- Preparation method of meto-Iodobenzylguanidine
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The invention relates to a preparation method of I-MIBG (meto-Iodobenzylguanidine). The method comprises the following steps: heating meto-Iodobenzylguanidine sulfate, stannous mono-sulphate, a reducing agent, copper sulfate and NaI in a boiling water bath, standing after finishing the reaction, taking a supernatant liquid, and filtering the supernatant liquid with a microfiltration membrane. Sodium thiosulfate and/or sodium thiosulfate are/is taken as the reducing agent to prepare the meto-Iodobenzylguanidine sulfate, the prepared I-MIBG is high in radiochemical purity and good in stability, and the radiochemical purity of the prepared I-MIBG is still at a relatively high level after 48 hours.
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Paragraph 0032; 0033
(2017/02/17)
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- Methods for purifying radiolabelled compounds
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One aspect of the present invention relates to a method of purifying radiolabelled compounds comprising a) loading onto a fluorous polymer a radiolabelled compound precursor comprising a fluoroalkyl tin moiety; b) reacting the radiolabelled compound precursor with a radiolabel delivering compound to give a radiolabelled compound, wherein the fluoroalkyl tin moiety is replaced by a radiolabel; and c) eluting the radiolabelled compound from the fluorous polymer.
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Page/Page column 16; 22
(2008/06/13)
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- Imaging agent and method of use
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A new radiopharmaceutical composition for use in nuclear medicine comprises a radioiodinated meta-iodobenzylguanidine. The composition is used as an imaging agent for the heart, adrenal medulla, and tumors of the adrenal medulla and can be used for treatm
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