- COMPOUNDS FOR TREATING CERTAIN LEUKEMIAS
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Provided herein are compounds, preferably compounds inhibiting tyrosine kinase enzymatic activity of a protein selected from Abelson protein (ABL1), Abelson-related protein (ABL2), or a chimeric protein BCR-ABL1, compositions thereof, and methods of their
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Paragraph 0541-0542
(2020/03/28)
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- Synthesis and binding properties of guanidinium biscarboxylates
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The ammonium ion binding site of the enzyme glutaminase HisF inspired us to design guanidinium biscarboxylates as potential self-organized ionophores in molecular recognition. The syntheses of the title compounds based on aliphatic and aromatic building b
- Spaeth, Andreas,Gonschor, Janina,Koenig, Burkhard
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experimental part
p. 1289 - 1308
(2012/06/15)
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- Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids
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The present invention relates to the field of prodrugs of chemotherapeutic agents and method of use thereof.
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- CARBEPENEM DERIVATIVES
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Carbapenem derivatives which may be utilized as antibiotics and which show strong antibacterial activity against various bacterial strains including Pseudomonas aeruginosa. The compounds containing the derivatives are quite safe and are also stable against hydrolases such as dehyropeptidase (DHP)
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- Diphosphonic acid compounds and use for calcium metabolism disorders
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The present invention provides compounds of the formula: STR1 The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them useful in treatment and prophylaxis of disorders of calcium metabolism.
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