- INHIBITORS OF SOLUBLE ADENYLYL CYCLASE
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Provided are 6-amino substituted 2,6-diamino-4-choropyrimidine compounds which are specific inhibitors of soluble adenylyl cyclase. The compounds can be formulated with pharmaceutical carriers and used for reducing cyclic AMP levels. The compositions can
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Paragraph 0145-0147
(2020/06/08)
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- IRAK DEGRADERS AND USES THEREOF
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The present invention provides compounds, compositions thereof, and methods of using the same.
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Paragraph 4084; 4086
(2019/07/10)
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- CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION
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The present invention relates to a hydroxyalkyl starch conjugate and a method for preparing the same, said hydroxyalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one secondary hydroxyl group, wherein the hydroxyalkyl starch is linked via said secondary hydroxyl group to the cytotoxic agent. The conjugate according to the present invention has a structure according to the following formula HAS′(-L-M)n wherein M is a residue of the cytotoxic agent, L is a linking moiety, HAS′ is the residue of the hydroxyalkyl starch derivative, and n is greater than or equal to 1, and wherein the hydroxyalkyl starch derivative has a mean molecular weight (MW) above the renal threshold.
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Paragraph 1159-1161
(2015/11/18)
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- PRODRUGS OF THERAPEUTIC COMPOUNDS
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The present invention provides compounds, pharmaceutical compositions and medicaments comprising such compounds, and the use of these compounds, compositions, and medicaments in methods of treating diseases and disorders such as cancers.
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Page/Page column 50; 51
(2012/11/13)
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- Analogs of the δ opioid receptor selective cyclic peptide [2-D- penicillamine,5-D-penicillamine]-enkephalin: 2',6'-Dimethyltyrosine and Gly3-Phe4 amide bond isostere substitutions
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In order to develop systemically-active opioid peptides, the δ-selective, opioid pentapeptide [D-Pen2,D-Pen5]-enkephalin (DPDPE) was modified by esterification and by substitution of 2',6'-dimethyltyrosine for tyrosine to yield 4. Co
- Chandrakumar,Stapelfeld,Beardsley,Lopez,Drury,Anthony,Savage,Williamson,Reichman
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p. 2928 - 2938
(2007/10/02)
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