Esterification of Amino Acids as Their 2,2-Bis(ethoxycarbonyl)vinyl Derivatives
A method to protect the amino group of the amino acids using diethyl (ethoxymethylene)malonate is described.The resulting derivatives are easily esterified with different alkylation agents.Elimination of the N-protecting group with bromine in chloroform a
Alaiz, Manuel,Giron, Julio,Hidalgo, Francisco Javier,Maza, Maria Pilar de la,Millan, Francisco,et al.
p. 544 - 547
(2007/10/02)
ETUDE D'UN SCHEMA DE SYNTHESE PEPTIDIQUE INTRAMOLECULAIRE A L'AIDE DE DERIVES DU PHOSPHORE TETRAEDRIQUE
A new scheme of repetitive and controlled peptide synthesis offers two advantages compared to the usual methods of synthesis: two steps only are used for the prolongation of a peptide chain with an amino-acid residue and the risk of racemisation is minimized.The two postulated steps are verified particularly by the rearrangement, in an alkaline alcoholic medium, of phosphordiamides 1 incorporating one amino-acid residue, leading to the formation of the peptide derivatives 6 and 8.The severe limitations of this method are discussed.
Mulliez, M.
p. 2027 - 2041
(2007/10/02)
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