- Bromelain catalyzed synthesis of peptides in organic solvent
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For the first time, immobilized bromelain was shown to maintain high catalytic activity in organic solvent and to form peptide bonds. It requires only 7 hours to obtain Cbz-Gly-L-Leu-OMe in 85% yield. The precursor of aspartame (Cbz-L-Asp-L-Phe-OMe) and other dipeptides were also synthesized by this method.
- Tai, Dar-Fu,Fu, Shu-Lin
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p. 179 - 183
(2007/10/03)
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- PREPARATION OF ESTERS OF AMINO ACIDS AND OF PEPTIDES UNDER MILD CONDITION
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A new method of obtaining esters of N-protected amino acids and peptides from complexes of their sodium salts with 15-crown-5 that are soluble in organic solvents is proposed.
- Mazurov, A. A.,Antonenko, S. V.,Andronati, S. A.
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p. 208 - 210
(2007/10/02)
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- STUDIES ON AMINO ACIDS AND PEPTIDES-III. 2,4-BIS(4-METHOXYPHENYL)-1,3,2,4-DITHIADIPHOSPHETANE 2,4-DISULFIDE, LR, AS A NEW RACEMIZATION FREE COUPLING REAGENT IN PEPTIDE SYNTHESIS
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The easily accesable 2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane 2,4-disulfide, LR, has been reacted with salts of N-protected amino acids 1 (Z-Gly-OH, Boc-Gly-OH, Boc-S-Ser(Bzl)-OH, Bos-S-Tyr(Bzl)-OH, Z-S-Arg(Z2)-OH, and Z-S-Pro-OH), at room tem
- Pedersen, U.,Thorsen, M.,El-Khrisy, E. -E. A. M.,Clausen, K.,Lawesson, S. -O.
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p. 3267 - 3269
(2007/10/02)
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