Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding site
Through high throughput screening, substituted proline sulfonamide 6 was identified as HCV NS5b RNA-dependent RNA polymerase inhibitor. Optimization of various regions of the lead molecule resulted in compounds that displayed good potency and selectivity.
Gopalsamy, Ariamala,Chopra, Rajiv,Lim, Kitae,Ciszewski, Gregory,Shi, Mengxiao,Curran, Kevin J.,Sukits, Steven F.,Svenson, Kristine,Bard, Joel,Ellingboe, John W.,Agarwal, Atul,Krishnamurthy, Girija,Howe, Anita Y. M.,Orlowski, Mark,Feld, Boris,O'Connell, John,Mansour, Tarek S.
p. 3052 - 3055
(2007/10/03)
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