Allyl as internucleotide protecting group in DNA synthesis to be cleaved off by ammonia
Deprotection of allyl groups from internucleotide phosphotriester functions can be achieved not only with Pd0-mediated cleavage in the presence of an appropriate nucleophile but also under standard conditions for DNA fragments using conc. ammon
The allylic protection method in solid-phase oligonucleotide synthesis. An efficient preparation of solid-anchored DNA oligomers
The first efficient synthesis of solid-anchored DNA oligomers has been realized; it relies on the use of allyl and (allyloxy)carbonyl groups as protectors of internucleotide linkage and nucleoside bases, respectively, in conjunction with palladium chemist
Hayakawa,Wakabayashi,Kato,Noyori
p. 1691 - 1696
(2007/10/02)
A NEW AND VERSATILE APPROACH TO THE PREPARATION OF VALUABLE DEOXYNUCLEOSIDE 3'-PHOSPHITE INTERMEDIATES
The easily accessible and crystalline monofunctional phosphitylating reagent bis-(diisopropylamino)chlorophosphine has been used for the synthesis of phosphoramidites and H-phosphonates of d-nucleosides and, also, the formation of 3'-5'-internucleotidic phosphonate bonds.
Marugg, J. E.,Burik, A.,Tromp, M.,Marel, G. A. van der,Boom, J. H. van
p. 2271 - 2274
(2007/10/02)
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