- Isotretinoin C15-triphenylphosphine chloride as well as preparation method and application thereof
-
The invention provides isotretinoin C15-triphenylphosphine chloride and a preparation method and application thereof. The preparation method comprises the steps of: stirring and mixing vinyl-beta-ionol, triethylamine and methyl alcohol to prepare a feed l
- -
-
Paragraph 0027-0053
(2020/08/17)
-
- Method for preparing vitamin A acetate
-
The invention belongs to the technical field of production of vitamin A and its derivatives, in particular to a method for preparing vitamin A acetate. The method comprises the following steps: (1) mixing triphenylphosphine and acid in supercritical CO2, and then contacting the obtained mixture with vinyl-beta-ionol for salt formation to obtain C15 phosphine salt; (2) after adding solvent water, ionic liquid and C5 aldehyde to the finished system of step (1) , CO2 is released for solvent replacement, and the materials are uniformly mixed; (3) adding an extractant to the system after the solvent replacement of step (2), stirring and adding an alkali solution for Wittig reaction to obtain the vitamin A acetate. The method of the invention has mild reaction conditions, safe production and easy control, and the purity and reaction yield of the final product are high.
- -
-
Paragraph 0060-0083
(2019/05/08)
-