- Short, convergent synthesis of locked retinals
-
We report a short and convenient synthesis of two configurationally locked retinals that are important for applications in the context of optogenetics. The C11-C15 cyclopentyl fragments of both retinals were obtained by palladium-catalysed alkoxycarbonylation and merged with the rest of the carbon skeleton through Wittig olefination. The preparation of the required and known ylide precursor was revisited and optimised. This synthetic route enables gram-scale preparation of both retinal derivatives.
- Andr?, Michal S.,Tzschucke, C. Christoph
-
-
Read Online
- Preparation method of vitamin A acetate
-
The invention provides a novel preparation method of vitamin A acetate, which comprises the following steps: 1-bromo-2-chloroethane is subjected to in-situ preparation of a Grignard reagent, then the Grignard reagent reacts with pentacarbaldehyde to prepare 3-methyl-6-chloro-2, 4-hexadienol acetate, and the 3-methyl-6-chloro-2, 4-hexadienol acetate is subjected to one-step in-situ Grignard reaction and beta-ionone reaction to obtain the vitamin A acetate. The process provides a C13 + C7 vitamin A acetate synthesis route, generation of triphenylphosphine oxide is avoided, modification solid acid is used for catalysis, VA deterioration is avoided, the yield of the vitamin A acetate is improved, the process cost is reduced, the reaction process is environmentally friendly, and industrial production is facilitated. The process cost is reduced, the reaction process is environment-friendly, and industrial production is facilitated.
- -
-
Paragraph 0059-0060
(2021/06/21)
-