N-demethylation of cyamemazine via non-classical Polonovski reaction and its conjugation to bovine serum albumin
A modified Polonovski reaction has been employed to obtain the N-demethylated metabolite of the neuroleptic drug cyamemazine. The synthesis involves N-oxide formation, isolation of the corresponding N-oxide, and a FeSO4·7H2O mediated Polonovski reaction to afford the desired monodesmethyl cyamemazine. In a subsequent step the hapten N-demethylcyamemazine-hemiglutarate was synthesized and its conjugated to bovine serum albumin (BSA).
Singh, Gurmit,Koerner, Terry B.,Godefroy, Samuel Benrejeb,Armand, Claude
p. 2160 - 2162
(2012/05/04)
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